Results 61 to 70 of about 23,189,783 (295)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Semen Analysis and Antisperm Antibody [PDF]

Archives of Andrology, 1998
Evaluation of the fertilizing potential of sperm is an important procedure in in vitro fertilization and embryo transfer (IVF-ET) clinic, in order to avoid performing invalid conventional IVF-ET or unnecessary intracytoplasmic sperm injection (ICSI). However, none of the standard semen parameters are reliable indices in predicting IVF outcome. The test
M, Kamada, S, Yamano, M, Senuma, K, Nakagawa, M, Maegawa, T, Aono   +5 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Quality of Bovine Chilled or Frozen-Thawed Semen after Addition of Omega-3 Fatty Acids Supplementation to Extender [PDF]

International Journal of Fertility and Sterility, 2013
Background: This study was conducted to evaluate the potential protective effects of omega-3 poly unsaturated fatty acids (Ω-3 PUFAs) on bovine sperm quality in response to cooling and cryopreservation.
Abbas Abavisani, Javad Arshami, Abbas Ali Naserian, Mohammad Ali Sheikholeslami Kandelousi, Mohammad Azizzadeh   +4 more
doaj  

Algorithms for Predicting the Probability of Azoospermia from Follicle Stimulating Hormone: Design and Multi-Institutional External Validation

The World Journal of Men's Health, 2022
Purpose: To predict the probability of azoospermia without a semen analysis in men presenting with infertility by developing an azoospermia prediction model. Materials and Methods: Two predictive algorithms were generated, one with follicle stimulating
Michael B. Tradewell, Walter Cazzaniga, Rodrigo L. Pagani, Rohit Reddy, Luca Boeri, Eliyahu Kresch, Luca A. Morgantini, Emad Ibrahim, Craig Niederberger, Andrea Salonia, Ranjith Ramasamy   +10 more
doaj   +1 more source

Semen Analysis and in vitro Fertilization [PDF]

Archives of Andrology, 1985
Thirty-seven patients underwent ultrasonographic, clinical, and hormonal monitoring of superovulated cycles in order to time HCG administration in an attempt to schedule the laparoscopy at the optimal time for oocyte recovery. Superovulation was induced by Clomiphene in patients under the age of 35, with both ovaries; Clomiphene and HMG were ...
L, Formigli, S, Al-Hasani, C, Roccio, L, Gottardi, G, Badulli   +4 more
openaire   +2 more sources

Semen Analysis in Fertiliser Factory Workers [PDF]

, 2019
Study case-control has been conducted to analyse the relationship of occupational exposure in fertilizer plant with semen analysis. The case is the exposed and control group is unexposed. The number of samples for each group was 27.
Nita, Sri, Setiawan, Arum, Hariani, Yulia   +2 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source