Results 31 to 40 of about 5,354,699 (289)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Optimal Design of Geared Joint for Semi-Active Knee Aid

Actuators
Knee flexion refers to the relative motion between the tibia and femur including rolling and sliding (rollback motion). Notwithstanding the individual variations in knee motion, conventional wearable knee-assistive devices use hinge joints—resulting in ...
Takehito Kikuchi, Kanta Omori, Miyu Fujisawa, Isao Abe   +3 more
doaj   +1 more source

Design of Solar Harvested Semi Active RFID Transponder with Supercapacitor Storage

Advances in Electrical and Electronic Engineering, 2015
This paper presents the analysis, design and manufacture of a low cost, low maintenance and long-range prototype of RFID transponder with continuous operability.
Gary Valentine, Lukas Vojtech, Marek Neruda   +2 more
doaj   +1 more source

A Semi‐active piezoelectric friction damper

Earthquake Engineering & Structural Dynamics, 2014
SummaryThis research investigates the development of a semi‐active piezoelectric friction damper for controlling the seismic response of large‐scale structures. The proposed device is made of Duplex steel and leads to high friction capacity, which can be developed either in passive or semi‐active modes.
Pardo Varela Javier Ignacio, De La Llera Martin Juan Carlos   +1 more
openaire   +4 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Energy harvesting using semi-active nonlinear control

, 2013
This paper presents the application of semi-active control for power harvesting using an electromechanical energy harvester. Two semi-active control strategies are proposed in the form of a time-periodic damper and a nonlinear cubic damper.
Ghandchi Tehrani, M., Bonisoli, Elvio, Ghandchi Tehrani, Maryam, Bonisoli, E., Di Monaco, Francesco, Di Monaco, F., Elliott, S.J.   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Semi-active radiofrequency power consumption sensor [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2012
A semi-active RF sensor of power consumption based on the transistor dynamic negatron was developed and investigated. The designed sensor has no mechanical parts and there is no electrical contact between the sensor and electrical grid, it can be ...
Lishchinskaya L. B., Lazarev A. A., Baraban M. V., Filinyuk N. A.   +3 more
doaj   +2 more sources