Results 51 to 60 of about 3,828,883 (311)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Semi-Supervised Active Learning in a pool-based scenario.
, 2016 Semi-Supervised Active Learning in a pool-based scenario.
Haifeng Li (142063) +6 more
core +1 more source
IET Electrical Systems in Transportation, 2021 Among new configurations of battery/supercapacitor (SC) hybrid energy storage systems (HESSs) for electric vehicles (EVs), several can be united under the common name of ‘switched structure’.
Ihor Shchur +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Isolation of anticlostridially active lactobacilli from semi-hard cheese
Czech Journal of Food Sciences, 2008 The group of 7 strains of facultatively heterofermentative lactobacilli (FHL) of the non starter lactic acid bacteria (NSLAB) isolated from semi-hard cheeses using a well agar diffusion assay possessed a different level of inhibition activity against 16 ...
Štěpán Tůma +2 more
doaj +1 more source
Adaptive Semi-Active Suspension and Cruise Control through LPV Technique
Applied Sciences, 2020 Several studies exist on topics of semi-active suspension and vehicle cruise control systems in the literature, while many of them just consider actual road distortions and terrain characteristics, these systems are not adaptive and their subsystems ...
Hakan Basargan +3 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Invariant points of semi-active suspensions
Advances in Mechanical Engineering, 2018 The invariant points of the quarter vehicle model shape many properties concerned in vehicle suspension design. Although they have been studied for years, the invariant points are still confusing for their different traits.
Shida Nie, Ye Zhuang, Fan Chen, Jie Xie
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source