Results 41 to 50 of about 49,747 (301)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Reinforcement-Learning-Based Vibration Control for a Vehicle Semi-Active Suspension System via the PPO Approach

Applied Sciences, 2022
The vehicle semi-active suspension system plays an important role in improving the driving safety and ride comfort by adjusting the coefficients of the damping and spring.
Shi-Yuan Han, Tong Liang
doaj   +1 more source

Fuzzy Control for Semi-Active Vehicle Suspension [PDF]

Journal of Low Frequency Noise, Vibration and Active Control, 2013
In this paper semi-active control of the suspension of an all-terrain vehicle is considered. A seven degree of freedom suspension model is presented first. A fuzzy approach for controller synthesis is then proposed. Expert knowledge is stored in the form of IF-THEN rules.
Sebastian Kurczyk, Marek Pawełczyk
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Design and performance evaluation of a novel fractional order PID control strategy for vehicle semi-active suspension

Advances in Mechanical Engineering
The performance of a semi-active suspension depends on the quality of the control algorithm. Considering the limitations of conventional PID controllers within intricate nonlinear systems, such as imprecise parameter tuning and performance deterioration,
Gang Li, Han Xu, Zhiyong Ruan, Qianjie Liu, Yu Gan, Lifan Yu, Wencai Zhu, Guoliang Hu   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An ARX Model-Based Predictive Control of a Semi-Active Vehicle Suspension to Improve Passenger Comfort and Road-Holding

Actuators, 2021
Passenger comfort and vehicle stability are key aspects that must be guaranteed on ground vehicles, and semi-active suspensions have offered an outstanding solution to meet these opposite objectives.
Alejandro Piñón, Antonio Favela-Contreras, Luis C. Félix-Herrán, Francisco Beltran-Carbajal, Camilo Lozoya   +4 more
doaj   +1 more source

An Investigation on Energy Recovery Analysis of Active Suspension System [PDF]

, 2013
Currently active suspension system is more applicable than passive for improving the suspension performance, ensuring the stability and passenger safety in modern automotive suspension system.
Gu, Fengshou, Tran, V.T., Ball, Andrew, Wang, R., Tran, Van Tung, Ball, A. D., Gu, F., Ball, A.D.   +7 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source