A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. [PDF]
, 2015 Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Bucko, Paula +8 more
core +1 more source
Clinical presentation, management and follow-up of 83 patients with Leydig cell tumors of the testis: a prospective case-cohort study [PDF]
, 2019 LCTs are more frequent than generally believed, are associated with male infertility, cryptorchidism and gynecomastia, and should be treated conservatively (in compliant patients) with active surveillance, which appears to be a safe alternative to ...
Cantisani, Vito +12 more
core +1 more source
Applications of spatial transcriptomics in studying spermatogenesis. [PDF]
AndrologyAbstract Spermatogenesis is a complex differentiation process that is facilitated by a series of cellular and molecular events. High‐throughput genomics approaches, such as single‐cell RNA sequencing, have begun to enable the systematic characterization of these events. However, the loss of tissue context because of tissue disassociations in the single‐
Xu Q, Chen H.
europepmc +2 more sources
Journal of Clinical Oncology, 2018 PURPOSE Residual lesions after chemotherapy are frequent in metastatic seminoma. Watchful waiting is recommended for lesions < 3 cm as well as for fluorodeoxyglucose (FDG) positron emission tomography (PET)-negative lesions ≥ 3 cm.
R. Cathomas +13 more
semanticscholar +1 more source
Cancers, 2019 Testicular germ cell tumors (GCTs) are very common in young men and can be stratified into seminomas and non-seminomas. While seminomas share a similar gene expression and epigenetic profile with primordial germ cells, the stem cell population of the non-
D. Nettersheim +4 more
semanticscholar +1 more source
Two decades of FDG-PET/CT in seminoma: exploring its role in diagnosis, surveillance and follow-up
Cancer Imaging, 2022 Background Survivors of testicular cancer may experience long-term morbidity following treatment. There is an unmet need to investigate techniques that can differentiate individuals who need additional therapy from those who do not.
Ciara Conduit +8 more
doaj +1 more source
A population-based case-control study on social factors and risk of testicular germ cell tumours [PDF]
, 2013 Objectives Incidence rates for testicular cancer have risen over the last few decades. Findings of an association between the risk of testicular cancer and social factors are controversial. The association of testicular cancer and different indicators of
Ahrens, W. +8 more
core +1 more source
Types of testicular tumors in Shahid Beheshti Hospital of Babol, Iran, during 2001‒2021 [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Testicular tumors account for about 1% of all male cancers. Considering that there is no accurate information about the prevalence of testicular tumors in Iran, this study aimed to investigate the types of testicular tumors in the hospitals ...
Sorena Samimi +2 more
doaj +1 more source
Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases [PDF]
, 2017 BACKGROUND: Cytotoxic therapy for relapsed and refractory germ cell tumors or metastatic sex cord stromal tumors is rarely effective and is often accompanied by high adverse event rates.
Albany, Costantine +5 more
core +1 more source
Cancer Medicine, 2018 The role of TDRG1 in tumorigenesis and the progression of seminoma, as well as its role in regulating chemosensitivity of seminoma to cisplatin through the PI3K/Akt/mTOR signaling pathway, has been previously defined.
Jingchao Wei +8 more
semanticscholar +1 more source