Results 21 to 30 of about 20,015 (227)

Testicular cancer and sperm DNA damage: short- and long-term effects of antineoplastic treatment [PDF]

, 2015
The aim of this study was to investigate sperm DNA damage induced by chemo- and radiotherapy in patients with testicular cancer to provide data on the extent and persistence of nuclear damage that might affect individual reproductive potential.
F. Rizzo, G. Leter, GALLO, MARIAGRAZIA, GANDINI, Loredana, LENZI, Andrea, LOMBARDO, Francesco, M. Spano, PAOLI, Donatella   +7 more
core   +1 more source

Spermatocytic Seminoma

Archives of Pathology & Laboratory Medicine, 2009
Abstract Spermatocytic seminoma is a rare germ cell tumor distinct from classical seminoma, both clinically and pathologically. It affects older men, has not been associated with a history of cryptorchidism, and has no known counterpart in ovary or any other site.
Nidhi, Aggarwal, Anil V, Parwani
openaire   +2 more sources

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity [PDF]

, 2017
The effects of microgravity on functions of the human body are well described, including alterations in the male and female reproductive systems. In the present study, TCam-2 cells, which are considered a good model of mitotically active male germ cells,
Catizone, A, Guarnieri, S, Mariggiò, M. A., Morabito, C, Ricci, G, Schiraldi, C   +5 more
core   +2 more sources

Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference [PDF]

, 2019
Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of ...
Almar E., Arveux P., Autelitano M., Baldi I., Bara S., Barchielli A., Benfatto L., Benhamou E., Bento M. J., Biasoni D., Bielska-Lasota M., Blaszczyk J., Bordoni A., Botta L., Bouchardy C., Bouvier A. -M., Bouvier V., Brewster D. H., Calleja N., Candela P., Capocaccia R., Carulla M., Catanzaro M. A., Clough-Gorr K., Colecchia M., Colonna M., Comber H., De Angelis R., de Lacerda G. F., de Munain A. L., Diaz Garcia J. M., Diba C. S., Dimitrova N., Dusek L., Engel J., Eycken E. V., Falcini F., Ferretti S., Filiberti R. A., Fusco M., Galceran J., Gatta G., Gavin A., Gennaro V., Gentilini M., Giacomin A., Gozdz S., Grosclaude P., Guizard A. -V., Hackl M., Heidrich J., Henau K., Holleczek B., Huws D. W., Iannelli A., Johannesen T. B., Jonasson J. G., Kepska K., Knijn A., Konzelmann I., Kunkler I., Lapotre-Ledoux B., Larranaga N., Leinonen M., Luttmann S., M. Ess S., Madeddu A., Magi M., Malila N., Mallone S., Mangone L., Marani E., Marcos-Gragera R., Maspero S., Maynadie M., Mazzoleni G., Michiara M., Miranda A., Molinie F., Monnereau A., Moreno-Iribas C., Mousavi M., Navarro C., Nennecke A., Nicolai N., Pannozzo F., Pierannunzio D., Piffer S., Pildava S., Primic-Zakelj M., Rachtan J., Rashbass J., Ricci P., Robaszkiewic M., Rossi S., Rugge M., Salmeron D., Sanchez M. J., Santaquilani M., Schubert-Fritschle G., Schvartz C., Sekerija M., Sensi F., Serraino D., Smailyte G., Spagnoli G., Stabenow R., Stracci F., Sutera Sardo A., Tagliabue G., Tavilla A., Torrella-Ramos A., Trama A., Tretarre B., Troussard X., Tumino R., Usala M., Velten M., Visser O., Vitale F., Woronoff A. -S., Ziino A.   +121 more
core   +1 more source

Clinical presentation, management and follow-up of 83 patients with Leydig cell tumors of the testis: a prospective case-cohort study [PDF]

, 2019
LCTs are more frequent than generally believed, are associated with male infertility, cryptorchidism and gynecomastia, and should be treated conservatively (in compliant patients) with active surveillance, which appears to be a safe alternative to ...
Cantisani, Vito, Fattorini, Giorgio, Franco, Giorgio, Gianfrilli, Daniele, Isidori, Andrea M, Lenzi, Andrea, Leonardo, Costantino, Pofi, Riccardo, Pozza, Carlotta, Sbardella, Emilia, Tarsitano, Maria Grazia, Tenuta, Marta, Testis, Unit   +12 more
core   +1 more source

Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination

Human Pathology: Case Reports, 2016
We experienced the giant seminoma with 18 × 10 × 10 cm sized and about 2.6 kg weight of 25 year old patient. We intensively examined the histological tissue type distributions in this giant seminoma. Most of the tumor consisted of seminoma components. In
Takeo Nakaya, MD, Shuichiro Kobayashi, MD, Satoshi Kitahara, MD, Akira Tanaka, MD, Hiroshi Kamma, MD, Akio Komatsu, MD   +5 more
doaj   +1 more source

Clusterin suppresses invasion and metastasis of testicular seminoma by upregulating COL15a1

Molecular Therapy: Nucleic Acids, 2021
Seminoma is the most common subtype of testicular germ cell tumor, with an increasing incidence worldwide. Clusterin (CLU) expression was found to be downregulated in testicular seminoma in our previous study. We now expanded the sample size, and further
Yankang Cui, Chenkui Miao, Shouyong Liu, Jingyuan Tang, Jing Zhang, Hengtao Bu, Yuhao Wang, Chao Liang, Meiling Bao, Chao Hou, Jiajin Wu, Xiaochao Chen, Xiang Zhang, Zengjun Wang, Bianjiang Liu   +14 more
doaj   +1 more source

Integrated Molecular Analysis Reveals 2 Distinct Subtypes of Pure Seminoma of the Testis

Cancer Informatics, 2022
Objective: Testicular germ cell tumors (TGCT) are the most common solid malignancy in adolescent and young men, with a rising incidence over the past 20 years.
Kirill E Medvedev, Anna V Savelyeva, Kenneth S Chen, Aditya Bagrodia, Liwei Jia, Nick V Grishin   +5 more
doaj   +1 more source

Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases [PDF]

, 2017
BACKGROUND: Cytotoxic therapy for relapsed and refractory germ cell tumors or metastatic sex cord stromal tumors is rarely effective and is often accompanied by high adverse event rates.
Albany, Costantine, Boyd, Thomas, Einhorn, Lawrence, Feldman, Darren R., Garbo, Lawrence, Josephson, Neil   +5 more
core   +1 more source

Two decades of FDG-PET/CT in seminoma: exploring its role in diagnosis, surveillance and follow-up

Cancer Imaging, 2022
Background Survivors of testicular cancer may experience long-term morbidity following treatment. There is an unmet need to investigate techniques that can differentiate individuals who need additional therapy from those who do not.
Ciara Conduit, Thuan Tzen Koh, Michael S Hofman, Guy C Toner, Jeremy Goad, Nathan Lawrentschuk, Keen-Hun Tai, Jeremy H Lewin, Ben Tran   +8 more
doaj   +1 more source