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seneR: An R package for comprehensive senescence assessment and its application in type 2 diabetes and osteoarthritis [PDF]
Computational and Structural Biotechnology JournalBackground: Cellular senescence is a key driver of aging and chronic diseases. However, accurately identifying senescent cells is challenging due to limitations of conventional biomarkers and senescence heterogeneity.
Yi Zhang +6 more
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Current Biology, 2022 Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators.
Varela-Eirín, Marta, Demaria, Marco
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Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression
Nucleus, 2022 Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
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A senescent cell bystander effect: senescence‐induced senescence [PDF]
Aging Cell, 2012 SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G +6 more
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Telomere Maintenance and the cGAS-STING Pathway in Cancer
Cells, 2022 Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them.
Hiroshi Ebata +2 more
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Nature Communications, 2022 Ras mutations induce cell competition and cellular senescence to inhibit the proliferation of oncogenic mutated cells. Here the authors demonstrate that cellular senescence inhibits cell competition-induced elimination of oncogenic cells through HGF ...
Nanase Igarashi +12 more
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ISRN Dermatology, 2011 Melanomas and nevi share many of the same growth-promoting mutations. However, melanomas grow relentlessly while benign nevi eventually undergo growth arrest and stabilize. The difference in their long-term growth potential may be attributed to activation of cellular senescence pathways.
Andrew L. Ross +2 more
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Communications Biology, 2022 Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP).
Sho Sugawara +20 more
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The Skin Epilipidome in Stress, Aging, and Inflammation
Frontiers in Endocrinology, 2021 Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface ...
Florian Gruber +10 more
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Developmental and age-related changes in apolipoprotein B mRNA editing in mice.
Journal of Lipid Research, 1992 Apolipoprotein B (apoB) mRNA is modified by a post-transcriptional editing reaction (C to U) changing a glutamine (CAA) to a translational stop codon (UAA) and producing apoB-48 mRNA in mammalian liver and intestine. Developmental and age-related changes
K Higuchi +3 more
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