Results 191 to 200 of about 479,194 (269)

Negligible Senescence

Frontiers in Genetics, 2012
openaire   +2 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A Bi-Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging-Related Metabolic Dysfunction. [PDF]

Adv Sci (Weinh)
Song Q, Du X, Dong W, Wang Y, Wang X, Yin Q.   +5 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Avian mesenchymal stem cell-derived extracellular vesicle alleviates the <i>Porphyromonas gingivalis</i> lipopolysaccharide induced gingival fibroblast senescence. [PDF]

J Dent Sci
Yang HC, Fu E, Chin YT, Shieh JS, Lin WN, Chiang CY.   +5 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Future directions of osteoanabolic therapies in osteoporosis: Integrating current anabolic agents and emerging senescence-targeted strategies. [PDF]

Best Pract Res Clin Rheumatol
Brooks HW, Cusick NC, Wu S, Farr JN.
europepmc   +1 more source

Senescence and Senescence-Related Disorders [PDF]

, 2013
openaire   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

A Novel Combination of <i>Galega officinalis</i> Extract, <i>Hippophae rhamnoides</i> Fruit Oil and Resveratrol Attenuates Bleomycin-Induced Senescence Markers in Human Dermal Fibroblasts and Ex Vivo Hair Follicles. [PDF]

Curr Issues Mol Biol
Lobo Aldezabal A, Cáceres Estévez I, Escobar Gómez Rodulfo M, Fernández-Martos S, Calvo-Sánchez M, Haya Rodríguez L, López Sánchez A, Nieto Botella L, Asín M, Carbajo JM, Espada Regalado J.   +10 more
europepmc   +1 more source