Results 201 to 210 of about 479,194 (269)

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Dual-Locked β‑Galactosidase/pH Near-Infrared Sensor Enables High-Fidelity Monitoring of Therapy-Induced Senescence. [PDF]

JACS Au
Ding L, Zhang Y, Wang N, Li Z, Jia L.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Integrative network toxicology and pharmacology reveal that kaempferol alleviates BaP-triggered pulmonary fibrosis via suppressing Ras/COX-2-dependent cellular senescence. [PDF]

Front Pharmacol
Zhao Q, Zhu D, Wu Z, Xia X, Li Y, Guo A, Xu Y, Zhou X.   +7 more
europepmc   +1 more source

<i>Polygonatum sibiricum</i> polysaccharide attenuates BMSC senescence by inhibiting NCOA4-mediated ferritinophagy. [PDF]

Pharm Biol
Dai X, Wang L, Sun Y, He Z, Du X, Lei X, Yang S, Li M.   +7 more
europepmc   +1 more source

Cellular Senescence and SASP in Bladder Ageing: Mechanisms and Emerging Interventions. [PDF]

Int J Gen Med
Yan J, Zhang D, Zhao F.
europepmc   +1 more source

Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation. [PDF]

Signal Transduct Target Ther
Zhou P, Wang Y, Cheng M, Deng F, Liu F, Chen X, Ning K, Mo D, Zeng Z, Huang Z, Dong Y, Wang Y, Zhang C, Qiao J, Yu Y, Pan H, Li R.   +16 more
europepmc   +1 more source