Results 221 to 230 of about 479,194 (269)
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Trends in Cognitive Sciences, 2017
The brain during healthy aging exhibits gradual deterioration of structure but maintains a high level of cognitive ability. These structural changes are often accompanied by reorganization of functional brain networks. Existing neurocognitive theories of aging have argued that such changes are either beneficial or detrimental.
Naik, S. +4 more
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The brain during healthy aging exhibits gradual deterioration of structure but maintains a high level of cognitive ability. These structural changes are often accompanied by reorganization of functional brain networks. Existing neurocognitive theories of aging have argued that such changes are either beneficial or detrimental.
Naik, S. +4 more
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SATB1, senescence and senescence‐related diseases
Journal of Cellular PhysiologyAbstractAging leads to an accumulation of cellular mutations and damage, increasing the risk of senescence, apoptosis, and malignant transformation. Cellular senescence, which is pivotal in aging, acts as both a guard against cellular transformation and as a check against cancer progression.
Wenjing Qi +4 more
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Nature, 1962
NEEDHAM1 has recently claimed that Minot's paradox2: “Senescence is at its maximum in the very young stages and the rate of senescence diminishes with age”, is false. Instead of the relationship Ṡ = Ġ (where Ṡ = rate of senescence, Ġ = specific growth-rate) indicated by Minot he advocates the use of the relationship Ṡ = k/Ġ in which, however, Ġ refers ...
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NEEDHAM1 has recently claimed that Minot's paradox2: “Senescence is at its maximum in the very young stages and the rate of senescence diminishes with age”, is false. Instead of the relationship Ṡ = Ġ (where Ṡ = rate of senescence, Ġ = specific growth-rate) indicated by Minot he advocates the use of the relationship Ṡ = k/Ġ in which, however, Ġ refers ...
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CNS & Neurological Disorders - Drug Targets, 2013
In order to understand microglial senescence it is important to also understand neuroinflammation because the distinction between senescent and activated microglia is a fine one to make and not always made easily. Indeed, it is not easy to reliably identify activated microglia which is why we spend some effort here discussing intricacies associated ...
Wolfgang J, Streit, Qing-Shan, Xue
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In order to understand microglial senescence it is important to also understand neuroinflammation because the distinction between senescent and activated microglia is a fine one to make and not always made easily. Indeed, it is not easy to reliably identify activated microglia which is why we spend some effort here discussing intricacies associated ...
Wolfgang J, Streit, Qing-Shan, Xue
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2022
Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and more recently in senescence. Evidence has accumulated that Gadd45a deficiency results in escape of mouse embryo fibroblasts from senescence, whereas Gadd45b deficiency promotes premature senescence and skin aging ...
M Raza, Zaidi, Dan A, Liebermann
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Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and more recently in senescence. Evidence has accumulated that Gadd45a deficiency results in escape of mouse embryo fibroblasts from senescence, whereas Gadd45b deficiency promotes premature senescence and skin aging ...
M Raza, Zaidi, Dan A, Liebermann
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Nature, 1961
WE owe to Minot1 a startling paradox—the view that the rate of senescence is most rapid at the beginning of life and slowest at the end: to quote the fourth of the laws by which he summarized his conclusions, “Senescence is at its maximum in the very young stages and the rate of senescence diminishes with age”.
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WE owe to Minot1 a startling paradox—the view that the rate of senescence is most rapid at the beginning of life and slowest at the end: to quote the fourth of the laws by which he summarized his conclusions, “Senescence is at its maximum in the very young stages and the rate of senescence diminishes with age”.
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Annual Review of Plant Biology, 2007
Leaf senescence constitutes the final stage of leaf development and is critical for plants’ fitness as nutrient relocation from leaves to reproducing seeds is achieved through this process. Leaf senescence involves a coordinated action at the cellular, tissue, organ, and organism levels under the control of a highly regulated genetic program.
Lim, PO, Kim, HJ, Nam, HG
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Leaf senescence constitutes the final stage of leaf development and is critical for plants’ fitness as nutrient relocation from leaves to reproducing seeds is achieved through this process. Leaf senescence involves a coordinated action at the cellular, tissue, organ, and organism levels under the control of a highly regulated genetic program.
Lim, PO, Kim, HJ, Nam, HG
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BioEssays, 1996
AbstractHuman life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require ...
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AbstractHuman life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require ...
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Journal of Voice, 1996
This paper draws together findings of recent studies examining changes in voice with aging. Listeners' accuracy in perceiving age from voice is discussed, along with changes in speaking fundamental frequency, fundamental frequency stability, temporal aspects of speech, and resonance features of voice with aging. Descriptions are provided of differences
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This paper draws together findings of recent studies examining changes in voice with aging. Listeners' accuracy in perceiving age from voice is discussed, along with changes in speaking fundamental frequency, fundamental frequency stability, temporal aspects of speech, and resonance features of voice with aging. Descriptions are provided of differences
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1984
As the nature of any intrinsic biologic aging process or even of its existence independent of disease is unknown, it is not possible to state whether or not the placenta gets old. As term approaches, the placenta accumulates a variety of lesions which seem pathological.
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As the nature of any intrinsic biologic aging process or even of its existence independent of disease is unknown, it is not possible to state whether or not the placenta gets old. As term approaches, the placenta accumulates a variety of lesions which seem pathological.
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