Results 231 to 240 of about 675,022 (305)

Cellular senescence in gastric cancer: a novel prognostic stratification and immune predictor. [PDF]

BMC Med Genomics
Wei CZ, Li YT, Lin ZH, Lin FZ, Chen XJ, Nie RC, Chen GM, Xue ZC, Zheng ZQ.   +8 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract. [PDF]

Aging Cell
Coquette C, Bouchoucha K, Mahieu M, Verleden SE, Loriot A, Norris K, Baird DM, Derumier A, Hoton D, De Sadeleer L, Vanstapel A, Vanaudenaerde BM, Goyet MV, Brichard B, Froidure A, Wuyts W, Van Slambrouck J, Ceulemans LJ, Trigaux W, Huart C, Decottignies A.   +20 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Aging cells, young patients: senescence in Hodgkin lymphoma. [PDF]

Blood Adv
Kong IY, Giulino-Roth L, Steidl C.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Integrative multi-omic analysis identified <i>ERBB2</i> mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer. [PDF]

Cancer Biol Med
Zhao Y, Wang H, Wang Y, Jiang Y, Hu X, Shao Z.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source