Results 241 to 250 of about 675,022 (305)

The triangular drivers of bone aging: mechanistic insights and therapeutic targets in cellular senescence, estrogen deficiency, and gut microenvironment dysregulation. [PDF]

Front Cell Dev Biol
Liu Z, Peng Y, Hou J, Zhang G, Wang J.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Senescence-Driven IL-17A Inflammatory Circuit Promotes Epithelial-Mesenchymal Transition (EMT) and Progression in Age-Related Posterior Subcapsular Cataracts. [PDF]

Aging Cell
Ni Y, Ma Y, Ren Z, Zhu Y, Liu L, Duan R, Qin L, Chen Y, Ju R, Qin Y, Wu M.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment. [PDF]

Aging Cell
Kasamoto J, González J, Markov Y, Sehgal R, Lee E, Dwaraka VB, Smith R, Higgins-Chen AT.   +7 more
europepmc   +1 more source

Comparative Analysis of Lavandula Dentata Rhizosphere Microbiota Across Different Developmental Stages in a Semi-Arid Area. [PDF]

Environ Microbiol Rep
Akachoud O, Langrand J, Bouamama H, Facon N, Laruelle F, Qaddoury A, Lounès-Hadj Sahraoui A.   +6 more
europepmc   +1 more source

Secretory products from regulatory macrophages modulate senescence in human endothelial cells: implications for cardiovascular aging and diseases. [PDF]

BMC Cardiovasc Disord
Delfs K, Berndt R, Hess K, Eimer C, Fändrich F, Steinfath M, Zitta K, Albrecht M.   +7 more
europepmc   +1 more source

Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues. [PDF]

Int J Mol Sci
Kim H, Kummerfeld E, Niedernhofer LJ, Aliferis C, Robbins PD, Wang J.   +5 more
europepmc   +1 more source