Results 261 to 270 of about 675,022 (305)
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Annals of Neurology, 1994
The immune system changes dramatically with age. There is a decline in the production of naive lymphocytes by the central lymphoid organs, the thymus and bone marrow. This leads to a reduced diversity and altered repertoire of antigen specificities recognized by the immune system.
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The immune system changes dramatically with age. There is a decline in the production of naive lymphocytes by the central lymphoid organs, the thymus and bone marrow. This leads to a reduced diversity and altered repertoire of antigen specificities recognized by the immune system.
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BioEssays, 1996
AbstractHuman life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require ...
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AbstractHuman life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require ...
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SATB1, senescence and senescence‐related diseases
Journal of Cellular PhysiologyAbstractAging leads to an accumulation of cellular mutations and damage, increasing the risk of senescence, apoptosis, and malignant transformation. Cellular senescence, which is pivotal in aging, acts as both a guard against cellular transformation and as a check against cancer progression.
Wenjing Qi +4 more
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Science Signaling
A metabolic switch enables hepatocytes in damaged livers to escape senescence and form tumors.
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A metabolic switch enables hepatocytes in damaged livers to escape senescence and form tumors.
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Journal of the American College of Radiology, 2016
Frank J, Lexa, David, Fessell
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Frank J, Lexa, David, Fessell
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Exploiting senescence for the treatment of cancer
Nature Reviews Cancer, 2022Liqin Wang +2 more
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Nature Reviews Molecular Cell Biology, 2020Raffaella Di Micco +2 more
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