Results 201 to 210 of about 12,101,411 (341)

Transcriptional Profiling at Single-Cell Resolution Reveals Diversity and Regulatory Networks of Primary and Secondary Senescent Cells. [PDF]

Aging Cell
Jang DH, Shim E, Shin JW, Kim S, Ciotlos S, Kim HJ, Gil TH, Kim Y, Jeon OH.   +8 more
europepmc   +1 more source

The Characteristics of Senescent Tumor Cells in Colorectal Cancer

DoctorⅠ. INTRODUCTION 1 1. Cellular Senescence and Cancer 1 2. Detection of Senescent Tumor Cells in Vitro and in Vivo 2 3. Cancer Promoting Features of Senescent Cells in cancer tissues 3 4.
박, 순상
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Clearance of Senescent Cells by BCL_XL-PROTAC: A Novel Approach to Treat COPD? [PDF]

Aging Cell
Devulder JV, Fenwick PS, Kolosionek E, Al-Sahaf M, Viola P, Lemaire R, Razdan N, Kudo H, Sinadinos A, Odqvist L, Donnelly LE, Barnes PJ.   +11 more
europepmc   +1 more source

Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain

GeroScience, 2022
T. Kiss, Ádám Nyúl-Tóth, J. Delfavero, Priya Balasubramanian, S. Tarantini, Janet Faakye, Rafał Gulej, C. Ahire, Anna Ungvari, A. Yabluchanskiy, G. Wiley, Lori Garman, Z. Ungvari, A. Csiszar   +13 more
semanticscholar   +1 more source

Cell senescence in cardiometabolic diseases

npj Aging
Cellular senescence has been implicated in many age-related pathologies including atherosclerosis, heart failure, age-related cardiac remodeling, diabetic cardiomyopathy and the metabolic syndrome. Here, we will review the characteristics of senescent cells and their endogenous regulators, and summarize the metabolic stressors that induce cell ...
openaire   +4 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Nature Medicine, 2017
Ok-hee Jeon, Chaekyun Kim, Rémi-Martin Laberge, M. Demaria, Sona Rathod, A. Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel E. David, D. Baker, J. V. van Deursen, J. Campisi, J. Elisseeff   +13 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type. [PDF]

Aging Cell
Goyer ML, Sonn A, Benabdallah B, Le O, Dulong J, Oschwald J, Sirois I, Apavaloaei A, Hesnard L, Guimond JV, Haddad E, Beauséjour C.   +11 more
europepmc   +1 more source