Results 201 to 210 of about 4,484,629 (285)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers. [PDF]

Aging Cell
Tripathi U, Suda M, Kulshreshtha V, Piatkowski BT, Palmer AK, Giorgadze N, Inman C, Gasek N, Xu M, Johnson KO, Pirtskhalava T, Chaib S, Langhi Prata LPG, Zhu Y, Kandhaya-Pillai R, Tullius SG, Wyles SP, Majji R, Yalamanchili HK, Allison DB, Tchkonia T, Kirkland JL.   +21 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Fisetin-Mediated Topical Modulation of Senescent Cells in Skin Improves Wound Healing Dynamics in Diabetic Mice. [PDF]

Adv Wound Care (New Rochelle)
Numani A, Carrasco-Jeldres M, Hernandez-Rovira B, Purushothaman KR, Melin MM, Kirkland JL, Wyles S.   +6 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Evaluation of statistical differential analysis methods for identification of senescent cells using single-cell transcriptomics. [PDF]

Cell Rep Methods
Li D, Liu P, Rahman I, Zand M, Pryhuber G, Dye T, Goniewicz M, Gurkar AU, Königshoff M, Eickelberg O, Mora A, Rojas M, Ma Q, Lugo-Martinez J, Bar-Joseph Z, Lanna S, Finkel T, Xie Z.   +17 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Correction to "Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells". [PDF]

Aging Cell
europepmc   +1 more source

Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions. [PDF]

Signal Transduct Target Ther
Mikawa T, Kameda M, Ikari S, Shibata E, Liu S, Miyagawa S, Ono K, Ito T, Yoshizawa A, Sugimoto M, Shibuya S, Shimizu T, Almunia J, Ogiso N, Revêchon G, Palazzo A, Bernard D, Kanda H, Soga T, Takubo K, Morioka S, Sasaki J, Sasaki T, Itamoto A, Fujii T, Seno H, Inagaki N, Kondoh H.   +27 more
europepmc   +1 more source