Results 221 to 230 of about 12,101,411 (341)

Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution. [PDF]

Biomolecules
Hsu JE, Wang B, Hwang Y, Cheng W, Zhao Q, Si Y, Xu M, Kang HM, Lee JH.   +8 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases. [PDF]

Nat Commun
Xu Q, Li G, Zhang H, Jiang Z, Gao X, Li Z, Langhi Prata LGP, Kirkland JL, Zhang G, Sun Y.   +9 more
europepmc   +1 more source

T cells as regulators of senescence [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells. [PDF]

Aging Cell
Zhang G, Zhang W, Wang C, Jiang Z, Xu Q, Li H, Kirkland JL, Wei G, Sun Y.   +8 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Structural evolution of carbon frameworks realizes in vitro interfacial transport in metabolically reprogrammed senescent cells for senolysis. [PDF]

Nat Commun
Wang X, Ma H, Li Y, Chen L, Ye C, Zhao Y, Wang H, Fu W, Yu C, Wang F, Yang S, Kang Y, Ding G, Li Z.   +13 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. [PDF]

Heart Rhythm
Sengun E, Zhou L, Kelsey M, Turan NN, Lu Y, Kabakov AY, Bronk P, Mi E, Kim TY, Vijayakumar S, Price D, Nussbaum SS, Song C, Feng J, Sellke FW, Dubielecka-Szczerba P, Del Monte F, Nerbonne J, Uydes-Dogan BS, Roder K, Choi BR, Van Wagoner DR, Sedivy JM, Koren G.   +23 more
europepmc   +1 more source