Results 241 to 250 of about 4,484,629 (285)
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The Journal of Pathology, 2013
AbstractCellular senescence is a key process that limits cancer development. The basics of our current understanding of the process are presented, including the genetic and epigenetic events that lead to the senescent phenotype. In addition to limiting replicative lifespan, senescence appears to act as a potent signal to activate immune clearance and ...
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AbstractCellular senescence is a key process that limits cancer development. The basics of our current understanding of the process are presented, including the genetic and epigenetic events that lead to the senescent phenotype. In addition to limiting replicative lifespan, senescence appears to act as a potent signal to activate immune clearance and ...
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Mechanisms of Ageing and Development, 1998
In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism.
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In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism.
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2006
The wear and tear processes that are thought to contribute to human ageing may play an important role in the development of vascular diseases. One such process is cellular senescence. In endothelial cells the senescent phenotype can be induced by a number of factors, including telomere damage, oxidative stress and sustained mitogenic stimulation ...
J D, Erusalimsky, D J, Kurz
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The wear and tear processes that are thought to contribute to human ageing may play an important role in the development of vascular diseases. One such process is cellular senescence. In endothelial cells the senescent phenotype can be induced by a number of factors, including telomere damage, oxidative stress and sustained mitogenic stimulation ...
J D, Erusalimsky, D J, Kurz
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1978
Publisher Summary Senescence is defined as an increase in the force of mortality with time—that is, the probability that an organism will die within a unit time interval successively increases with the age of the organism. As it is seen in this chapter, this crude definition contains a multitude of hidden pitfalls and obscurities that must be ...
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Publisher Summary Senescence is defined as an increase in the force of mortality with time—that is, the probability that an organism will die within a unit time interval successively increases with the age of the organism. As it is seen in this chapter, this crude definition contains a multitude of hidden pitfalls and obscurities that must be ...
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Immunosurveillance of senescent cells: the bright side of the senescence program
Biogerontology, 2013Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to mediate tumor suppression and control the tissue damage response following short-term insults. In addition, the senescence associated-secretory phenotype (SASP), one of the most profound characteristics of the senescence program, facilitates the ...
Adi Sagiv, Valery Krizhanovsky
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The cell fate: senescence or quiescence
Molecular Biology Reports, 2016Senescence and quiescence are frequently used as interchangeable terms in the literature unwittingly. Despite the fact that common molecules play role in decision of cell cycle arrest, senescent and quiescent cells have some distinctive phenotypes at both molecular and morphological levels.
Menderes Yusuf, Terzi +2 more
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Cell Sorting of Young and Senescent Cells
2013Cellular senescence is the irreversible loss of proliferative potential and is accompanied by a number of phenotypic changes. First described by Hayflick and Moorhead in 1961, it has since become a popular model to study cellular aging. The replicative lifespan of human fibroblasts is heterogeneous even in clonal populations, with the fraction of ...
Hewitt G, Von Zglinicki T, Passos JF
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Mitochondria, telomeres and cell senescence
Experimental Gerontology, 2005The accumulation of oxidative damage is one of the most widely accepted causes of ageing. Mitochondrial dysfunction, in particular damage to the mitochondrial DNA has been hypothesised, more than thirty years ago, as responsible for increased production of reactive oxygen species (ROS) and, thus, as one possible causal factor for ageing. There is now a
Passos JF, Von Zglinicki T
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Hematopoietic cells and replicative senescence
Experimental Gerontology, 2002Replicative senescence describes the finite cell replicative capacity in response to chronic proliferative stimulation. A key element in this process is the shortening of the telomeres, which to a major extent is caused by the lack of expression of telomerase.
Rita B, Effros, Amiela, Globerson
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In vitro Senescence of Mammalian Cells
Gerontology, 2009This review discusses the molecular and cytokinetic aspects of cellular aging of human diploid fibroblasts. Despite a large amount of data, the basis of their limited life span has not been defined. A replicative defect in aging cells lies in the mechanism(s) that initiates DNA synthesis, and the control of this mechanism(s) is mediated through an ...
B K, Choe, N R, Rose
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