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Studying Hepatic Stellate Cell Senescence
2023Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis.
Sandra A, Serna-Salas +4 more
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Antiaging Vaccines Targeting Senescent Cells
Rejuvenation Research, 2022The development of senomorphic drugs to attenuate the senescent phenotype and senolytics to clear pro-inflammatory senescent cells (SCs) to treat aging-associated disorders is being hotly pursued. The effort is complicated by the fact that SCs play a constructive role in some cellular processes such as tissue repair and wound healing. However, concerns
Andrew R, Mendelsohn, James W, Larrick
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1978
Publisher Summary Senescence is defined as an increase in the force of mortality with time—that is, the probability that an organism will die within a unit time interval successively increases with the age of the organism. As it is seen in this chapter, this crude definition contains a multitude of hidden pitfalls and obscurities that must be ...
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Publisher Summary Senescence is defined as an increase in the force of mortality with time—that is, the probability that an organism will die within a unit time interval successively increases with the age of the organism. As it is seen in this chapter, this crude definition contains a multitude of hidden pitfalls and obscurities that must be ...
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The Journal of Pathology, 2013
AbstractCellular senescence is a key process that limits cancer development. The basics of our current understanding of the process are presented, including the genetic and epigenetic events that lead to the senescent phenotype. In addition to limiting replicative lifespan, senescence appears to act as a potent signal to activate immune clearance and ...
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AbstractCellular senescence is a key process that limits cancer development. The basics of our current understanding of the process are presented, including the genetic and epigenetic events that lead to the senescent phenotype. In addition to limiting replicative lifespan, senescence appears to act as a potent signal to activate immune clearance and ...
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Senescent cells in tissue engineering
Current Opinion in Biotechnology, 2022Tissue engineers have long worked to develop cells, biomaterial matrices, and signaling molecules designed to restore or promote the repair of lost or damaged tissue. Senescent cells (SnCs), that is, cells that have entered permanent cell-cycle arrest, exert powerful cell non-autonomous effects on their local environments.
Alexander F, Chin, Jennifer H, Elisseeff
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Mechanisms of Ageing and Development, 1998
In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism.
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In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism.
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2013
Cellular senescence processes affecting tissue resident stem cells are considered, at present, an hallmark of both aging and age-related pathologies. Therefore it is mandatory to address this problem with adequate techniques that could highlight the molecular alterations associated with this complex cellular response to stressors.
CESSELLI, Daniela +5 more
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Cellular senescence processes affecting tissue resident stem cells are considered, at present, an hallmark of both aging and age-related pathologies. Therefore it is mandatory to address this problem with adequate techniques that could highlight the molecular alterations associated with this complex cellular response to stressors.
CESSELLI, Daniela +5 more
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Hematopoietic cells and replicative senescence
Experimental Gerontology, 2002Replicative senescence describes the finite cell replicative capacity in response to chronic proliferative stimulation. A key element in this process is the shortening of the telomeres, which to a major extent is caused by the lack of expression of telomerase.
Rita B, Effros, Amiela, Globerson
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2004
Abstract Cell senescence appears carefully arranged as cells divide; aging appears to be a more haphazard affair. For cells, this has prompted a semantic distinction between aging and senescence, but organisms may age or senesce without fear of scholarly argument.
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Abstract Cell senescence appears carefully arranged as cells divide; aging appears to be a more haphazard affair. For cells, this has prompted a semantic distinction between aging and senescence, but organisms may age or senesce without fear of scholarly argument.
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Epigenetic regulation in cell senescence
Journal of Molecular Medicine, 2017Cell senescence, which is an irreversible state of cell proliferative arrest, has emerged as a potentially important contributor to tissue dysfunction and organismal ageing. Cell senescence is triggered by a variety of senescence stressors, which affect gene expression and multiple signalling pathways that give rise to various senescence phenotypes ...
Li-Qin, Cheng +3 more
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