Results 271 to 280 of about 112,157 (308)
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Gerontology, 2016
Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during aging, including the skin. Senescent cells secrete proinflammatory cytokines, chemokines, growth factors, and proteases, a phenomenon called senescence-associated secretory phenotype (SASP), which are thought to contribute to the functional decline of ...
Velarde, Michael C., Demaria, Marco
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Senescent cells are induced by a wide variety of stimuli. They accumulate in several tissues during aging, including the skin. Senescent cells secrete proinflammatory cytokines, chemokines, growth factors, and proteases, a phenomenon called senescence-associated secretory phenotype (SASP), which are thought to contribute to the functional decline of ...
Velarde, Michael C., Demaria, Marco
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Mitochondria, telomeres and cell senescence
Experimental Gerontology, 2005The accumulation of oxidative damage is one of the most widely accepted causes of ageing. Mitochondrial dysfunction, in particular damage to the mitochondrial DNA has been hypothesised, more than thirty years ago, as responsible for increased production of reactive oxygen species (ROS) and, thus, as one possible causal factor for ageing. There is now a
Passos JF, Von Zglinicki T
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Ceramide induces endothelial cell senescence
Cell Biochemistry and Function, 2009AbstractCeramide has been proposed to be a mediator of replicative senescence. Our aim was to determine whether ceramide induces senescence in vascular endothelial cells. Human umbilical vein endothelial cells were cultured to different population doubling levels and ceramide levels were quantitated. The endogenous levels of ceramide increased 2.4‐fold
Mark E, Venable, Xinhe, Yin
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Alarmin Detection in Senescent Cells
2018Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP member. HMGB1 relocalization from the nucleus provides a molecular signature during senescence.
Dong Eun, Kim, Albert R, Davalos
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Senescence and Cell Cycle Control
2006In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene activation, normal cells undergo cellular senescence, which is a stable postmitotic state with particular morphology and metabolism.
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Cellular Senescence and Senescent Cell*
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012Pu WANG +5 more
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Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
Cell, 2023Shadmehr Demehri
exaly