Results 291 to 300 of about 12,101,411 (341)
Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice. [PDF]
PNAS NexusMadhurakkat Perikamana S +8 more
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SenNet recommendations for detecting senescent cells in different tissues
Nature Reviews Molecular Cell BiologyVidyani Suryadevara +2 more
exaly +2 more sources
Therapeutic targeting of senescent cells in the CNS
Nature Reviews Drug DiscoveryMarkus Riessland +2 more
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The challenge of identifying senescent cells
Nature Cell Biology, 2023Jesús Gil
semanticscholar +4 more sources
NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates
Science Translational Medicine, 2023Cellular senescence, characterized by stable cell cycle arrest, plays an important role in aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged tissues and ameliorates age-associated diseases.
Dong Yang +10 more
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Advances in Nanotherapy for Targeting Senescent Cells
International Journal of NanomedicineYurou Shi,1,2,* Yingjie Zhang,1,* Yaxuan Zhang,2 Jiali Yao,2 Junping Guo,3 Xiaoling Xu,2 Lijun Wang1 1Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical ...
Xiao-Ling Xu
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Nature Reviews Cancer, 2001
Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce ...
N F, Mathon, A C, Lloyd
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Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce ...
N F, Mathon, A C, Lloyd
openaire +2 more sources
Frontiers in Bioscience, 2001
The aging of the immune system, referred to as immunosenescence, is associated with a dramatic reduction in responsiveness as well as functional dysregulation. This deterioration of immune function with advancing age contributes to the increased incidence among the elderly of morbidity and mortality from infectious disease, and possibly autoimmunity ...
P, Linton, M L, Thoman
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The aging of the immune system, referred to as immunosenescence, is associated with a dramatic reduction in responsiveness as well as functional dysregulation. This deterioration of immune function with advancing age contributes to the increased incidence among the elderly of morbidity and mortality from infectious disease, and possibly autoimmunity ...
P, Linton, M L, Thoman
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2006
The wear and tear processes that are thought to contribute to human ageing may play an important role in the development of vascular diseases. One such process is cellular senescence. In endothelial cells the senescent phenotype can be induced by a number of factors, including telomere damage, oxidative stress and sustained mitogenic stimulation ...
J D, Erusalimsky, D J, Kurz
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The wear and tear processes that are thought to contribute to human ageing may play an important role in the development of vascular diseases. One such process is cellular senescence. In endothelial cells the senescent phenotype can be induced by a number of factors, including telomere damage, oxidative stress and sustained mitogenic stimulation ...
J D, Erusalimsky, D J, Kurz
openaire +2 more sources