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Senescent cells in tissue engineering
Current Opinion in Biotechnology, 2022Tissue engineers have long worked to develop cells, biomaterial matrices, and signaling molecules designed to restore or promote the repair of lost or damaged tissue. Senescent cells (SnCs), that is, cells that have entered permanent cell-cycle arrest, exert powerful cell non-autonomous effects on their local environments.
Alexander F, Chin, Jennifer H, Elisseeff
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Mechanisms of Ageing and Development, 2022
Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific differences exist and the mechanism(s) by which this sex-by-age interaction influences CVD development and progression remains elusive.
N. Salerno +11 more
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Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific differences exist and the mechanism(s) by which this sex-by-age interaction influences CVD development and progression remains elusive.
N. Salerno +11 more
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1978
Publisher Summary Senescence is defined as an increase in the force of mortality with time—that is, the probability that an organism will die within a unit time interval successively increases with the age of the organism. As it is seen in this chapter, this crude definition contains a multitude of hidden pitfalls and obscurities that must be ...
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Publisher Summary Senescence is defined as an increase in the force of mortality with time—that is, the probability that an organism will die within a unit time interval successively increases with the age of the organism. As it is seen in this chapter, this crude definition contains a multitude of hidden pitfalls and obscurities that must be ...
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The Journal of Pathology, 2013
AbstractCellular senescence is a key process that limits cancer development. The basics of our current understanding of the process are presented, including the genetic and epigenetic events that lead to the senescent phenotype. In addition to limiting replicative lifespan, senescence appears to act as a potent signal to activate immune clearance and ...
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AbstractCellular senescence is a key process that limits cancer development. The basics of our current understanding of the process are presented, including the genetic and epigenetic events that lead to the senescent phenotype. In addition to limiting replicative lifespan, senescence appears to act as a potent signal to activate immune clearance and ...
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Mechanisms of Ageing and Development, 1998
In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism.
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In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism.
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Acta Biomaterialia, 2022
Systemic elimination of senescent cells using senolytic drugs presents therapeutic effects on age-related diseases, including senile osteoporosis.
X. Xing +12 more
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Systemic elimination of senescent cells using senolytic drugs presents therapeutic effects on age-related diseases, including senile osteoporosis.
X. Xing +12 more
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Immunosurveillance of senescent cells: the bright side of the senescence program
Biogerontology, 2013Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to mediate tumor suppression and control the tissue damage response following short-term insults. In addition, the senescence associated-secretory phenotype (SASP), one of the most profound characteristics of the senescence program, facilitates the ...
Adi Sagiv, Valery Krizhanovsky
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The cell fate: senescence or quiescence
Molecular Biology Reports, 2016Senescence and quiescence are frequently used as interchangeable terms in the literature unwittingly. Despite the fact that common molecules play role in decision of cell cycle arrest, senescent and quiescent cells have some distinctive phenotypes at both molecular and morphological levels.
Menderes Yusuf, Terzi +2 more
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Mitochondria, telomeres and cell senescence
Experimental Gerontology, 2005The accumulation of oxidative damage is one of the most widely accepted causes of ageing. Mitochondrial dysfunction, in particular damage to the mitochondrial DNA has been hypothesised, more than thirty years ago, as responsible for increased production of reactive oxygen species (ROS) and, thus, as one possible causal factor for ageing. There is now a
Passos JF, Von Zglinicki T
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Cell Sorting of Young and Senescent Cells
2013Cellular senescence is the irreversible loss of proliferative potential and is accompanied by a number of phenotypic changes. First described by Hayflick and Moorhead in 1961, it has since become a popular model to study cellular aging. The replicative lifespan of human fibroblasts is heterogeneous even in clonal populations, with the fraction of ...
Hewitt G, Von Zglinicki T, Passos JF
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