Results 311 to 320 of about 12,101,411 (341)
Some of the next articles are maybe not open access.
Hematopoietic cells and replicative senescence
Experimental Gerontology, 2002Replicative senescence describes the finite cell replicative capacity in response to chronic proliferative stimulation. A key element in this process is the shortening of the telomeres, which to a major extent is caused by the lack of expression of telomerase.
Rita B, Effros, Amiela, Globerson
openaire +2 more sources
2013
Cellular senescence processes affecting tissue resident stem cells are considered, at present, an hallmark of both aging and age-related pathologies. Therefore it is mandatory to address this problem with adequate techniques that could highlight the molecular alterations associated with this complex cellular response to stressors.
CESSELLI, Daniela +5 more
openaire +3 more sources
Cellular senescence processes affecting tissue resident stem cells are considered, at present, an hallmark of both aging and age-related pathologies. Therefore it is mandatory to address this problem with adequate techniques that could highlight the molecular alterations associated with this complex cellular response to stressors.
CESSELLI, Daniela +5 more
openaire +3 more sources
In vitro Senescence of Mammalian Cells
Gerontology, 2009This review discusses the molecular and cytokinetic aspects of cellular aging of human diploid fibroblasts. Despite a large amount of data, the basis of their limited life span has not been defined. A replicative defect in aging cells lies in the mechanism(s) that initiates DNA synthesis, and the control of this mechanism(s) is mediated through an ...
B K, Choe, N R, Rose
openaire +2 more sources
2004
Abstract Cell senescence appears carefully arranged as cells divide; aging appears to be a more haphazard affair. For cells, this has prompted a semantic distinction between aging and senescence, but organisms may age or senesce without fear of scholarly argument.
openaire +1 more source
Abstract Cell senescence appears carefully arranged as cells divide; aging appears to be a more haphazard affair. For cells, this has prompted a semantic distinction between aging and senescence, but organisms may age or senesce without fear of scholarly argument.
openaire +1 more source
Cellular Senescence and Senescent Cell*
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012Pu WANG +5 more
openaire +1 more source
Cancers and the concept of cell senescence
Biogerontology, 2009The post-mitotic cell reached by normal cell populations after serial divisions has been regarded as the hallmark of cell senescence. It was proposed that this non-dividing cell is a mechanism of protection against malignant transformation and different approaches have been used to induce the post-mitotic state.
openaire +2 more sources
Senescence and Cell Cycle Control
2006In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene activation, normal cells undergo cellular senescence, which is a stable postmitotic state with particular morphology and metabolism.
openaire +2 more sources
Senescent cells support limb regeneration
Nature Reviews Molecular Cell Biology, 2023Paulina Strzyz, Strzyz Paulina
exaly
Influence of Exercise on Exhausted and Senescent T Cells: A Systematic Review
Frontiers in Physiology, 2021Thomasina Donovan +2 more
exaly