Results 231 to 240 of about 112,157 (308)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

Freizus N, Majewska J, Ovadya Y, Kopitman E, Porat Z, Mayo A, Meir-Salame T, Dassa B, Stelzer G, Alon U, Krizhanovsky V.   +10 more
europepmc   +1 more source

Senescent cells promote viral infection-associated inflammation and tissue damage through a robust NF-κB pathway. [PDF]

Cell Commun Signal
Tian M, Ma J, Li Z, Ye C, Cui X, Wang G, Liu S, Qudus MS, Afaq U, Fan H, Xiong J, Li G, Luo C, Wang Z, Jin Z, Guo M, Wang X, Huang Z, Zheng F, Wu K, Zhu C.   +20 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells? [PDF]

Front Cell Dev Biol
Kasperova BJ, Cinkajzlova A, Horvath L, Svoboda P, Haluzik M, Stemberkova Hubackova S.   +5 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Targeting senescent cells for the treatment of age-associated diseases. [PDF]

J Biochem
Suda M, Tchkonia T, Kirkland JL, Minamino T.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

<i>Lactiplantibacillus plantarum</i>OLL2712 Protects From the Intestinal Dysfunction in D-Galactose Induced Senescent Cells. [PDF]

Food Sci Nutr
Watanabe-Yasuoka Y, Watanabe R, Gotou A, Nakajima-Adachi H, Hachimura S, Sashihara T.   +5 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source