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Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential. [PDF]

Aging Dis
Kureel SK, Rasmussen BB.
europepmc   +1 more source

Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low-Frequency Ultrasound. [PDF]

Aging Cell
Kureel SK, Maroto R, Aniqua M, Powell S, Singh E, Margadant F, Blair B, Rasmussen BB, Sheetz MP.   +8 more
europepmc   +1 more source

Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system. [PDF]

Biogerontology
Salminen A, Kaarniranta K, Kauppinen A.
europepmc   +1 more source

Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

Freizus N, Majewska J, Ovadya Y, Kopitman E, Porat Z, Mayo A, Meir-Salame T, Dassa B, Stelzer G, Alon U, Krizhanovsky V.   +10 more
europepmc   +1 more source

Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply. [PDF]

Aging Cell
Huang Z, Liu X, Zhou X, Chen K, Diao H, Wang M, Wei J, Li Z, Yang Y, Mao Z, Yu W.   +10 more
europepmc   +1 more source

Advances in Nanotherapy for Targeting Senescent Cells [PDF]

International Journal of Nanomedicine
Yurou Shi,1,2,* Yingjie Zhang,1,* Yaxuan Zhang,2 Jiali Yao,2 Junping Guo,3 Xiaoling Xu,2 Lijun Wang1 1Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical ...
Xiaoling Xu
exaly   +1 more source

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Cell senescence and cancer

Nature Reviews Cancer, 2001
Historically, the senescent state has been associated with, and was named after, the cell-cycle arrest that occurs after cells have undergone an intrinsically defined number of divisions in vitro. More recently, however, it has been shown that extrinsic factors, including those encountered in normal tissue-culture environments, can prematurely induce ...
N F, Mathon, A C, Lloyd
openaire   +2 more sources

T cell senescence

Frontiers in Bioscience, 2001
The aging of the immune system, referred to as immunosenescence, is associated with a dramatic reduction in responsiveness as well as functional dysregulation. This deterioration of immune function with advancing age contributes to the increased incidence among the elderly of morbidity and mortality from infectious disease, and possibly autoimmunity ...
P, Linton, M L, Thoman
openaire   +2 more sources