Results 81 to 90 of about 3,543,475 (319)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A Simulation Study for Optimal Pinhole Collimator Design in Gamma Camera Systems

Journal of Medical Physics
Background: The usage of a semiconductor detector with a pinhole collimator can provide high spatial resolution due to its high intrinsic resolution. However, the collimator system has low sensitivity due to the hole’s small diameter.
M. A. Ghoneim
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Dielectrically Modulated Single Schottky Barrier and Electrostatically Doped Drain Based FET for Biosensing Applications

IEEE Access
In this work, we propose a novel Gate and Drain Engineered Schottky Barrier (SB) FET (GDE-SBFET) for biosensing application with significant sensitivity improvement.
Faisal Bashir, Furqan Zahoor, Haider Abbas, Ali Alzahrani, Mehwish Hanif   +4 more
doaj   +1 more source

Comparison of sensitivity of psychophysical and electrophysiological measures of scotopic thresholds in the vicinity of the blind spot [PDF]

, 1967
William H. Payne
openalex   +1 more source

TTT and TTP Diagrams of Quenching Sensitivity of Al-7.5Zn-1.6Mg-2.0cu Alloy

, 2021
Liangliang Bao, Youping Yi, Chen Li, Shiquan Huang, Dang Wang, Shenglei Gao   +5 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Sensitivity-Based Algorithm Approach in Reconstructing Images in Electrical Impedance Tomography

IEEE Access
Electrical impedance tomography (EIT) is a medical imaging technique used to reconstruct images inside the domain of interest. EIT collects data on the boundary of the domain to infer the conductivity distribution inside the domain.
Rose Anne D. Alas, Arrianne Crystal T. Velasco   +1 more
doaj   +1 more source