Results 121 to 130 of about 2,654,059 (402)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Accuracy of MUAC in the detection of severe wasting with the new WHO growth standards. [PDF]
, 2010 OBJECTIVES: The objectives of this study were to estimate the accuracy of using mid-upper-arm circumference (MUAC) measurements to diagnose severe wasting by comparing the new standards from the World Health Organization (WHO) with those from the US ...
Delchevalerie, P +2 more
core +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 2013 Introduction Rapid diagnostic tests (RDTs) may improve the early detection of visceral leishmaniasis (VL), but their real-world performance requires additional study.
Alexandre Sampaio Moura +3 more
doaj +1 more source
Proper Estimation of Sensitivity and Specificity [PDF]
Clinical and Vaccine Immunology, 2006 I write to express concern about the diagnostic accuracy statements of Eda et. al. concerning a new Johne's disease enzyme-linked immunosorbent assay (ELISA) (2). The diagnostic sensitivity of this new ELISA for bovine paratuberculosis, reported to be 100%, was based on only 64 (according to the Materials and Methods) or 51 (according to the Results)
openaire +2 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Clinical Epidemiology, 2019 Ren Jie Robert Yao,1 Jason G Andrade,1 Marc W Deyell,1 Heather Jackson,2 Finlay A McAlister,3 Nathaniel M Hawkins11Division of Cardiology, University of British Columbia, Vancouver, Canada; 2Cardiac Services British Columbia, Vancouver, Canada; 3Division
Yao RJR +5 more
doaj
Psychometric Properties of Persian Version of Checklist for Autism in Toddlers (CHAT)
مجله دانشکده پزشکی اصفهان, 2019 Background: The increasing rate of autism spectrum disorder highlights the need for early screening with the aim to provide early intervention. This study aimed to provide Persian version of Checklist for Autism in Toddlers (CHAT) and assess its ...
Amrollah Ebrahimi +5 more
doaj +1 more source
Mechanisms of Sensitivity and Specificity in Olfaction
Cold Spring Harbor Symposia on Quantitative Biology, 1992 The sensitivity and specificity of the mammalian olfactory system is the result of the contributions at the anatomical, cellular, and biochemical levels. The recent identification of a large gene family encoding putative olfactory receptors suggests that genetic diversity may play an important role in this system. Future challenges lie in understanding
openaire +2 more sources