Results 121 to 130 of about 2,526,766 (401)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Screening Characteristics of Ultrasonography in Detection of Ankle Fractures

Emergency, 2016
Introduction: Ankle fracture is one of the most common joint fractures. X-ray and physical examination are itsmain methods of diagnosis. Recently, ultrasonography (US) is considered as a simple and non-invasive methodof fracture diagnosis.
Majid Shojaee, Farhad Hakimzadeh, Parisa Mohammadi, Anita Sabzghabaei, Mohammad Manouchehrifar, Ali Arhami Dolatabadi   +5 more
doaj  

A Non-Specific Cutaneous Sensitivity Which is Passively Transferable with the Serum to the Normal Human Skin [PDF]

, 1932
Matthew Walzer
openalex   +1 more source

Sensitivity, Specificity, and Predictive Values: Foundations, Pliabilities, and Pitfalls in Research and Practice

Frontiers in Public Health, 2017
Within the context of screening tests, it is important to avoid misconceptions about sensitivity, specificity, and predictive values. In this article, therefore, foundations are first established concerning these metrics along with the first of several ...
Robert Trevethan
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

SENSITIVITY OF THE TUBERCLE BACILLUS TO STREPTOMYCIN BEFORE AND DURING SPECIFIC THERAPY 123 [PDF]

, 1948
Joseph F. Sadusk, William E. Swift, Eleanora Falco, John Vadney   +3 more
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Gait Verification using Knee Acceleration Signals [PDF]

, 2011
A novel gait recognition method for biometric applications is proposed. The approach has the following distinct features. First, gait patterns are determined via knee acceleration signals, circumventing difficulties associated with conventional vision ...
Chang, D. J., Hang, L. W., Hong, C. Y., Nagurka, Mark L., Yen, C. W.   +4 more
core   +1 more source

Diagnostic accuracy of urine dipstick testing for albumin-to-creatinine ratio and albuminuria: A systematic review and meta-analysis

Heliyon, 2021
Background: The accuracy of urine dipsticks to detect increased albuminuria is uncertain. We aimed to assess the diagnostic accuracy of urine dipsticks for detecting albuminuria.
Jhonatan R. Mejia, Jose Ernesto Fernandez-Chinguel, Gandy Dolores-Maldonado, Naysha Becerra-Chauca, Sergio Goicochea-Lugo, Percy Herrera-Añazco, Jessica Hanae Zafra-Tanaka, Alvaro Taype-Rondan   +7 more
doaj  

Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody. [PDF]

, 1966
WF Rosse, J. V. Dacie
openalex   +1 more source