Results 91 to 100 of about 1,078,264 (264)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Soil Sensitivity Index as an Indicator for Climate-Smart Urban ForestrySoil Sensitivity Index as an Indicator for Climate-Smart Urban Forestry

Geopauta
Concept of climate-smart forestry, designed for mountain forests, was modified and applied to urban forest areas which are under high anthropogenic and climate change pressures.
Milica Kašanin-Grubin, Nevena Antić, Sanja Stojadinović, Nikola Živanović, Vukašin Rončević, Snežana Štrbac   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Translation and validation of the Ukrainian version of the visceral sensitivity index for patients with irritable bowel syndrome. [PDF]

Prz Gastroenterol, 2023
Neverovskyi A, Shypulin V, Mikhnova N.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Factor structure of the anxiety sensitivity index-3 in a sample of older adults. [PDF]

Eur J Ageing, 2022
Robinson A, Weitzner DS, Calamia M.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Thyristor Controlled Series Capacitor for Generation reallocation Using Firefly algorithm to avoid Voltage instability

Majlesi Journal of Electrical Engineering
Modern electric power utilities are facing many challenges due to increasing complexity in their operation and structure. In the recent times, one of the problems that got wide attention is the power system instabilities due to lack of new transmission ...
Venkata Gundavarapu, Venkateswara Bathina   +1 more
doaj  

Assisted reproductive technology and interactions between serum basal FSH/LH and ovarian sensitivity index. [PDF]

Front Endocrinol (Lausanne), 2023
He Y, Liu L, Yao F, Sun C, Meng M, Lan Y, Yin C, Sun X.   +7 more
europepmc   +1 more source