Results 31 to 40 of about 91,363 (358)
Frontiers in Physiology, 2021 LEP is a pleiotropic gene and the actions of leptin extend well beyond simply acting as the signal of the size of adipose tissue stores originally proposed.
Charles A. LeDuc +2 more
doaj +1 more source
The potential role and application of PARP inhibitors in cancer treatment [PDF]
, 2009 Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core +2 more sources
p53 is required for chloroquine-induced atheroprotection but not insulin sensitization[S]
Journal of Lipid Research, 2010 An intact genotoxic stress response appears to be atheroprotective and insulin sensitizing. ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and ...
Babak Razani +2 more
doaj +1 more source
Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway. [PDF]
PLoS ONE, 2012 This study was to investigate the effect of nicotine on insulin sensitivity and explore the underlying mechanisms. Treatment of Sprague-Dawley rats with nicotine (3 mg/kg/day) for 6 weeks reduced 43% body weight gain and 65% blood insulin level, but had ...
Tian-Ying Xu +6 more
doaj +1 more source
Role of adipokines in sarcopenia
Chinese Medical Journal, 2023 . Sarcopenia is an age-related disease that mainly involves decreases in muscle mass, muscle strength and muscle function. At the same time, the body fat content increases with aging, especially the visceral fat content.
Wenhao Lu +6 more
doaj +1 more source
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
core +2 more sources
Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. [PDF]
, 2016 Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, the notion that most genetic variance in populations is additive.
Bloom, Joshua S +4 more
core +3 more sources
Nutrition & Metabolism, 2011 Background Quercetin derivatives in onions have been regarded as the most important flavonoids to improve diabetic status in cells and animal models. The present study was aimed to examine the hypoglycemic and insulin-sensitizing capacity of onion peel ...
Kim Ji Yeon +4 more
doaj +1 more source
Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity [PDF]
, 2016 Objective: This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of ...
Alfadda +39 more
core +1 more source
Kulturella Perspektiv, 2004 Pimples can, when they appear, claim much more space in life than just the spots in the face. For the one who is badly affected, pimples become central for the way in which the person acts, feels and experiences the world. The many hours in front of the
Linda Sturesson Witt
doaj +1 more source