Results 61 to 70 of about 18,846 (144)

Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery

Microbial Cell Factories, 2017
Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the ...
Sambandam Ravikumar, Mary Grace Baylon, Si Jae Park, Jong-il Choi   +3 more
doaj   +1 more source

Identification of Novel Thermosensors in Gram-Positive Pathogens

Frontiers in Molecular Biosciences, 2020
Temperature is a crucial variable that every living organism, from bacteria to humans, need to sense and respond to in order to adapt and survive. In particular, pathogenic bacteria exploit host-temperature sensing as a cue for triggering virulence gene ...
Pilar Fernández, Alejandra Raquel Díaz, María Florencia Ré, Lucía Porrini, Diego de Mendoza, Diego de Mendoza, Daniela Albanesi, Daniela Albanesi, María Cecilia Mansilla, María Cecilia Mansilla   +9 more
doaj   +1 more source

Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella

mBio, 2016
The two-component system BvgAS controls the expression of the virulence regulon of Bordetella pertussis. BvgS is a prototype of bacterial sensor kinases with extracytoplasmic Venus flytrap perception domains.
E. Lesne, E.-M. Krammer, E. Dupre, C. Locht, M. F. Lensink, R. Antoine, F. Jacob-Dubuisson   +6 more
doaj   +1 more source

Ethanolamine Activates a Sensor Histidine Kinase Regulating Its Utilization in Enterococcus faecalis [PDF]

Journal of Bacteriology, 2008
ABSTRACT Enterococcus faecalis is a gram-positive commensal bacterium of the human intestinal tract. Its opportunistic pathogenicity has been enhanced by the acquisition of multiple antibiotic resistances, making the treatment of enterococcal infections an increasingly difficult problem.
Del Papa, María Florencia, Perego, Marta   +1 more
openaire   +3 more sources

Genetic evidence for histidine kinase HP165 being an acid sensor of Helicobacter pylori [PDF]

FEMS Microbiology Letters, 2004
Helicobacter pylori is a human gastric pathogen which is extremely well adapted to its unique habitat. Crucial for the survival under the acidic conditions prevailing in the stomach is the enzyme urease. Transcriptome analysis has shown that transcription of a large number of genes responds to the exposure of H.
Michael, Pflock, Patricia, Dietz, Jennifer, Schär, Dagmar, Beier   +3 more
openaire   +2 more sources

Pyrimidine sufficiency is required for Sae two-component system signaling in Staphylococcus aureus

Journal of Bacteriology
Nucleotide metabolism in pathogens is essential for their virulence, supporting their growth, survival, and immune evasion during infection. Virulence in Staphylococcus aureus is driven by the production of virulence factors that facilitate nutrient ...
Dennis A. DiMaggio, Won-Sik Yeo, Shaun R. Brinsmade   +2 more
doaj   +1 more source

A two-component regulatory system in transcriptional control of photosystem stoichiometry: redox-dependent and sodium ion-dependent phosphoryl transfer from cyanobacterial histidine kinase Hik2 to response regulators Rre1 and RppA

Frontiers in Plant Science, 2016
I hereby submit the above-titled manuscript for publication in Frontiers in Plant Science. The research reported is original and novel. No part of it is submitted for publication elsewhere.We report on regulation and interactions of a unique histidine ...
Iskander Mohamed Ibrahim, Sujith ePuthiyaveetil, John Frederick Allen   +2 more
doaj   +1 more source

Signal Sensing and Transduction by Histidine Kinases as Unveiled through Studies on a Temperature Sensor

Accounts of Chemical Research, 2017
Histidine kinases (HK) are the sensory proteins of two-component systems, responsible for a large fraction of bacterial responses to stimuli and environmental changes. Prototypical HKs are membrane-bound proteins that phosphorylate cognate response regulator proteins in the cytoplasm upon signal detection in the membrane or periplasm.
Luciano A. Abriata, Daniela Albanesi, Matteo Dal Peraro, Diego de Mendoza   +3 more
openaire   +4 more sources

Leveraging the histidine kinase-phosphatase duality to sculpt two-component signaling

Nature Communications
Bacteria must constantly probe their environment for rapid adaptation, a crucial need most frequently served by two-component systems (TCS). As one component, sensor histidine kinases (SHK) control the phosphorylation of the second component, the ...
Stefanie S. M. Meier, Elina Multamäki, Américo T. Ranzani, Heikki Takala, Andreas Möglich   +4 more
doaj   +1 more source

Sensor kinase KinB and its pathway‐associated key factors sense the signal of nutrition starvation in sporulation of Bacillus subtilis

MicrobiologyOpen, 2018
Bacillus subtilis responds to environmental stress cues and develops endospores for survival. In the process of endospore formation, sporulation initiation is a vital stage and this stage is governed by autophosphorylation of the sensor histidine kinases.
Weipeng Liu, Zeying He, Feng Gao, Jinyuan Yan, Xiaowei Huang   +4 more
doaj   +1 more source