Results 41 to 50 of about 18,846 (144)

regO: a novel locus in the regulation of tetrapyrrole biosynthesis in Rhodospirillum rubrum

Annals of Microbiology, 2023
Purpose A new locus, regO, involved in the regulation of photosynthesis gene expression in response to oxygen and light, has been studied in Rhodosprillum rubrum ATCC1117 (Rsp. rubrum) for identification of its function.
Manar Mansour, Khaled Abou-Aisha
doaj   +1 more source

KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally

Nature Communications
Two-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli.
Jakob M. Silberberg, Sophie Ketter, Paul J. N. Böhm, Kristin Jordan, Marcel Wittenberg, Julia Grass, Inga Hänelt   +6 more
doaj   +1 more source

The accessory protein CvnF8 modulates histidine kinase activity in an actinobacterial G protein system in Streptomyces coelicolor

mBio
Conservons are operons that encode unusual regulatory systems found in bacteria of the phylum Actinomycetota. These regulatory systems are composed of four core proteins: a sensor histidine kinase-like protein (CvnA homolog), an MglB-type roadblock ...
Luis M. Cantu Morin, Kilian Dekoninck, Kyung-Yoon Min, Matthew F. Traxler   +3 more
doaj   +1 more source

Vancomycin does not affect the enzymatic activities of purified VanSA.

PLoS ONE, 2019
VanS is a membrane-bound sensor histidine kinase responsible for sensing vancomycin and activating transcription of vancomycin-resistance genes. In the presence of vancomycin, VanS phosphorylates the transcription factor VanR, converting it to its ...
Elizabeth C Upton, Lina J Maciunas, Patrick J Loll   +2 more
doaj   +1 more source

Structural and Functional Aspects of the Sensor Histidine Kinase PrrB from Mycobacterium tuberculosis [PDF]

Structure, 2006
We describe the solution structures of two- and three-domain constructs of the sensor histidine kinase PrrB from Mycobacterium tuberculosis, which allow us to locate the HAMP linker relative to the ATP binding and dimerization domains. We show that the three-domain construct is active both for autophosphorylation and for phosphotransfer to the cognate ...
Nowak, E., Panjikar, S., Morth, J.P., Jordanova, R., Svergun, D.I., Tucker, P.A.   +5 more
openaire   +4 more sources

Diversity of function and higher-order structure within HWE sensor histidine kinases [PDF]

Journal of Biological Chemistry, 2020
Abstract Integral to the protein structure/function paradigm, oligomeric state is typically conserved along with function across evolution. However, notable exceptions such as the hemoglobins show how evolution can alter oligomerization to enable new regulatory mechanisms. Here we examine this linkage in histidine kinases (HKs), a large
Igor Dikiy, Danielle Swingle, Kaitlyn Toy, Uthama R. Edupuganti, Giomar Rivera-Cancel, Kevin H. Gardner   +5 more
openaire   +2 more sources

Genetic and biochemical dissection of a HisKA domain identifies residues required exclusively for kinase and phosphatase activities.

PLoS Genetics, 2012
Two-component signal transduction systems, composed of histidine kinases (HK) and response regulators (RR), allow bacteria to respond to diverse environmental stimuli.
Jonathan W Willett, John R Kirby
doaj   +1 more source

Crystal structure of a histidine kinase sensor domain with similarity to periplasmic binding proteins [PDF]

Proteins: Structure, Function, and Bioinformatics, 2009
Histidine kinase receptors are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes, where they are crucial for environmental adaption through the coupling of extracellular changes to intracellular responses. The typical two-component system consists of a membrane-spanning histidine kinase sensor and
Jonah, Cheung, Matthew, Le-Khac, Wayne A, Hendrickson   +2 more
openaire   +2 more sources

A Unique GTP-Dependent Sporulation Sensor Histidine Kinase in Bacillus anthracis [PDF]

Journal of Bacteriology, 2009
ABSTRACT The Bacillus anthracis BA2291 gene codes for a sensor histidine kinase involved in the induction of sporulation. Genes for orthologs of the sensor domain of the BA2291 kinase exist in virulence plasmids in this organism, and these proteins, when expressed, inhibit sporulation by converting BA2291 ...
Francesca, Scaramozzino, Andrea, White, Marta, Perego, James A, Hoch   +3 more
openaire   +2 more sources

Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System

Microorganisms, 2021
Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE.
Alexandra A. Guffey, Patrick J. Loll
doaj   +1 more source