Results 31 to 40 of about 18,846 (144)

A Ligand-Induced Switch in the Periplasmic Domain of Sensor Histidine Kinase CitA [PDF]

Journal of Molecular Biology, 2008
Sensor histidine kinases of two-component signal-transduction systems are essential for bacteria to adapt to variable environmental conditions. However, despite their prevalence, it is not well understood how extracellular signals such as ligand binding regulate the activity of these sensor kinases.
Sevvana, M., Vijayan, V., Zweckstetter, M., Reinelt, S., Madden, D., Herbst-Irmer, R., Sheldrick, G., Bott, M., Griesinger, C. ; https://orcid.org/0000-0002-1266-4344, Becker, S.   +9 more
openaire   +4 more sources

Domain shuffling in a sensor protein contributed to the evolution of insect pathogenicity in plant-beneficial Pseudomonas protegens.

PLoS Pathogens, 2014
Pseudomonas protegens is a biocontrol rhizobacterium with a plant-beneficial and an insect pathogenic lifestyle, but it is not understood how the organism switches between the two states.
Peter Kupferschmied, Maria Péchy-Tarr, Nicola Imperiali, Monika Maurhofer, Christoph Keel   +4 more
doaj   +1 more source

Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases

Nature Communications, 2020
Bacterial two-component systems are composed of a sensor histidine kinase (HK) and an effector response regulator and upon signal detection, the HK autophosphorylates a conserved His residue.
Cristina Mideros-Mora, Laura Miguel-Romero, Alonso Felipe-Ruiz, Patricia Casino, Alberto Marina   +4 more
doaj   +1 more source

Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains. [PDF]

PLoS Biology, 2013
Two-component systems (TCSs) are important for the adaptation and survival of bacteria and fungi under stress conditions. A TCS is often composed of a membrane-bound sensor histidine kinase (SK) and a response regulator (RR), which are relayed through ...
Chen Wang, Jiayan Sang, Jiawei Wang, Mingyan Su, Jennifer S Downey, Qinggan Wu, Shida Wang, Yongfei Cai, Xiaozheng Xu, Jun Wu, Dilani B Senadheera, Dennis G Cvitkovitch, Lin Chen, Steven D Goodman, Aidong Han   +14 more
doaj   +1 more source

The ArcB leucine zipper domain is required for proper ArcB signaling. [PDF]

PLoS ONE, 2012
The Arc two-component system modulates the expression of numerous genes in response to respiratory growth conditions. This system comprises ArcA as the response regulator and ArcB as the sensor kinase. ArcB is a tripartite histidine kinase whose activity
Luis Alberto Nuñez Oreza, Adrián F Alvarez, Imilla I Arias-Olguín, Alfredo Torres Larios, Dimitris Georgellis   +4 more
doaj   +1 more source

A role for the essential YycG sensor histidine kinase in sensing cell division [PDF]

Molecular Microbiology, 2010
SummaryThe YycG sensor histidine kinase co‐ordinates cell wall remodelling with cell division in Gram‐positive bacteria by controlling the transcription of genes for autolysins and their inhibitors. Bacillus subtilis YycG senses cell division and is enzymatically activated by associating with the divisome at the division septum.
Fukushima T, Furihata I, Emmins R, Daniel RA, Hoch JA, Szurmant H   +5 more
openaire   +3 more sources

Phosphatase activity tunes two-component system sensor detection threshold

Nature Communications, 2018
Two-component systems are a major family of signal transduction pathways and a rich source of sensors for biotechnology. Here, the authors develop a general method for rationally tuning two-component system input detection thresholds via specific point ...
Brian P. Landry, Rohan Palanki, Nikola Dyulgyarov, Lucas A. Hartsough, Jeffrey J. Tabor   +4 more
doaj   +1 more source

Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases. [PDF]

PLoS ONE, 2015
Hybrid sensor kinase, which contains a histidine kinase (HK) domain, a receiver domain, and a histidine-containing phosphotransmitter (HPt) domain, conveys signals to its cognate response regulator by means of a His-Asp-His-Asp phosphorelay.
Emiko Kinoshita-Kikuta, Eiji Kinoshita, Yoko Eguchi, Shiho Yanagihara, Keisuke Edahiro, Yuki Inoue, Momoka Taniguchi, Myu Yoshida, Kaneyoshi Yamamoto, Hirotaka Takahashi, Tatsuya Sawasaki, Ryutaro Utsumi, Tohru Koike   +12 more
doaj   +1 more source

Two‐component sensor histidine kinases of Mycobacterium tuberculosis: Beacons for niche navigation

Molecular Microbiology, 2022
AbstractIntracellular bacterial pathogens such as Mycobacterium tuberculosis are remarkably adept at surviving within a host, employing a variety of mechanisms to counteract host defenses and establish a protected niche. Constant surveying of the environment is key for pathogenic mycobacteria to discern their immediate location and coordinate the ...
Miljan Stupar, Juanelle Furness, Christopher J. De Voss, Lendl Tan, Nicholas P. West   +4 more
openaire   +4 more sources

Role of the Transporter-Like Sensor Kinase CbrA in Histidine Uptake and Signal Transduction [PDF]

Journal of Bacteriology, 2015
ABSTRACT CbrA is an atypical sensor kinase found in Pseudomonas . The autokinase domain is connected to a putative transporter of the sodium/solute symporter family (SSSF). CbrA functions together with its cognate response regulator, CbrB, and plays an important role in nutrient acquisition, including ...
Zhang, Xue Xian, Gauntlett, Jonathan C., Oldenburg, Darby G., Cook, Gregory M., Rainey, Paul B.   +4 more
openaire   +4 more sources