A Transmembrane Histidine Kinase Functions as a pH Sensor [PDF]
Biomolecules, 2020 The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature variations.
Ana Bortolotti +8 more
doaj +6 more sources
Diversity in Sensing and Signaling of Bacterial Sensor Histidine Kinases [PDF]
Biomolecules, 2021 Two-component signal transduction systems (TCSs) are widely conserved in bacteria to respond to and adapt to the changing environment. Since TCSs are also involved in controlling the expression of virulence, biofilm formation, quorum sensing, and ...
Eiji Ishii, Yoko Eguchi
doaj +3 more sources
Structural basis of molecular logic OR in a dual-sensor histidine kinase. [PDF]
Proc Natl Acad Sci U S A, 2019 Signal detection and integration by sensory proteins constitute the critical molecular events as living organisms respond to changes in a complex environment. Many sensory proteins adopt a modular architecture that integrates the perception of distinct chemical or physical signals and the generation of a biological response in the same protein molecule.
Shin H +4 more
europepmc +4 more sources
A unique sensor histidine kinase. [PDF]
J Bacteriol, 2009 Sporulation initiation in Bacillus species is controlled by an extended version of two-component signal transduction systems, termed phosphorelay ([4][1]). The cascade of His→Asp→His→Asp phosphotransfer is typically initiated by the ATP-dependent autophosphorylation of the histidine ...
Tzeng YL.
europepmc +4 more sources
Routes of phosphoryl group transfer during signal transmission and signal decay in the dimeric sensor histidine kinase ArcB [PDF]
Journal of Biological Chemistry, 2018 Hortencia Silva-Jiménez +2 more
exaly +2 more sources
The LytS-type histidine kinase BtsS is a 7-transmembrane receptor that binds pyruvate
mBio, 2023 LytS/LytTR-type histidine kinase/response regulator systems regulate crucial host-specific mechanisms during infection of human or plant hosts. Escherichia coli has two of them, and the histidine kinase BtsS is a high-affinity sensor for extracellular ...
Jin Qiu +4 more
doaj +1 more source
Cell fate regulation governed by a repurposed bacterial histidine kinase. [PDF]
PLoS Biology, 2014 One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via ...
W Seth Childers +6 more
doaj +1 more source
Mechanism of transmembrane signaling by sensor histidine kinases [PDF]
Science, 2017 Bacterial sensing mechanism revealed Escherichia coli use a transmembrane sensor protein to sense nitrate in their external environment and initiate a biochemical response. Gushchin et al.
Ivan Gushchin +15 more
openaire +4 more sources
Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes [PDF]
Genome Biology and Evolution, 2018 Histidine kinases (HKs) are primary sensor proteins that act in cell signaling pathways generically referred to as "two-component systems" (TCSs). TCSs are among the most widely distributed transduction systems used by both prokaryotic and eukaryotic organisms to detect and respond to a broad range of environmental cues.
Kabbara, Samar +10 more
openaire +3 more sources
Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS
iScience, 2021 Summary: Bacterial two-component regulatory systems are ubiquitous environment-sensing signal transducers involved in pathogenesis and antibiotic resistance.
Zhenlin Ouyang +10 more
doaj +1 more source