Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase [PDF]
Nature Communications, 2017 Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a ...
Oskar Berntsson +19 more
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Structural insights into the histidine-containing phosphotransfer protein and receiver domain of sensor histidine kinase suggest a complex model in the two-component regulatory system in Pseudomonas aeruginosa [PDF]
IUCrJ, 2020 In Pseudomonas aeruginosa, an important opportunistic pathogen that causes numerous acute and chronic infections, the hybrid two-component system (TCS) regulates the swarming ability and biofilm formation with a multistep phosphorelay, and consists of ...
Shao-Kang Chen +11 more
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Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase [PDF]
mBio, 2021 Bacteria employ two-component systems (TCSs) to sense and respond to changes in their surroundings. At the core of the TCS signaling pathway is the multidomain sensor histidine kinase, where the enzymatic activity of its output domain is allosterically ...
Jimena Rinaldi +13 more
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 [PDF]
Microbiology SpectrumRalstonia pseudosolanacearum strain OE1-1 secretes methyl 3-hydroxymyristate (3-OH MAME) as a quorum-sensing (QS) signal. Strain OE1-1 senses the chemical by the sensor histidine kinase PhcS, leading to the activation of the LysR family transcriptional ...
Wakana Senuma +7 more
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Signaling ammonium across membranes through an ammonium sensor histidine kinase [PDF]
Nature Communications, 2018 For anammox bacteria, the sensing and uptake of ammonium is essential and specialized proteins, like Ks-Amt5, mediate such processes. Here, authors perform biophysical, biochemical, and structural analysis on Ks-Amt5 and establish a role for this protein
Tobias Pflüger +9 more
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Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS. [PDF]
PLoS ONE, 2013 Clostridium perfringens is ubiquitous in nature and is often found as a commensal of the human and animal gastrointestinal tract. It is the primary etiological agent of clostridial myonecrosis, or gas gangrene, a serious infection that results in ...
Thomas J Hiscox +7 more
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Crystal Structure of a Proteolytic Fragment of the Sensor Histidine Kinase NarQ
Crystals, 2020 Two-component signaling systems (TCSs) are a large and important class of sensory systems in bacteria, archaea, and some eukaryotes, yet their mechanism of action is still not fully understood from the structural point of view.
Ivan Gushchin +4 more
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Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts [PDF]
International Journal of Molecular Sciences, 2020 Valentin Gordeliy +2 more
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Conformational dynamics of the essential sensor histidine kinase WalK [PDF]
Acta Crystallographica Section D: Structural Biology, 2017 Yongfei Cai +2 more
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High-level cefiderocol and ceftazidime/avibactam resistance in KPC-producing Klebsiella pneumoniae associated with mutations in KPC and the sensor histidine kinase EnvZ [PDF]
Journal of Antimicrobial ChemotherapyMatteo Boattini +2 more
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