Results 61 to 70 of about 206,198 (250)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)

Cancer Medicine
Background Survivors of childhood central nervous system (CNS) tumors can develop motor and sensory impairment from their cancer and treatment history.
Rozalyn L. Rodwin, Fang Wang, Lu Lu, Zhenghong Li, Deo Kumar Srivastava, Nicholas S. Phillips, Raja B. Khan, Tara M. Brinkman, Kevin R. Krull, Frederick A. Boop, Gregory T. Armstrong, Thomas E. Merchant, Amar Gajjar, Leslie L. Robison, Melissa M. Hudson, Nina S. Kadan‐Lottick, Kirsten K. Ness   +16 more
doaj   +1 more source

Persistently short or long sleep duration increases the risk of sensory impairment in Chinese older adults

Frontiers in Public Health
BackgroundCross-sectional evidence suggests that persistently short or long sleep duration is associated with sensory impairment. Thus, this study was conducted to investigate the associations between sleep duration and altered sleep duration with ...
Ling Yang, Jing Du, Ying Duan, Yan Cui, Qi Qi, Zihao Liu, Huaqing Liu   +6 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Severity of dual sensory loss and cognitive impairment in institutionalized older adults: a cross-sectional study in Galicia

BMC Geriatrics
Background Few studies have examined sensory impairment (visual and auditory) as a risk factor for cognitive impairment in older people living in nursing homes. This study analysed the combined effect of visual and auditory impairment (dual sensory loss)
Covadonga Vázquez-Sánchez, Luz María Gigirey Prieto, Carlos Pío del Oro-Sáez   +2 more
doaj   +1 more source

Contribution of social activity participation to the relationship between sensory impairment, physical performance and cognitive decline: a longitudinal study in China

Frontiers in Aging Neuroscience
ObjectivesThis study examined the impact of sensory impairment (hearing and/or vision) combined with poor physical performance on cognitive decline and assessed whether social activity participation mediated this relationship.MethodsMultilevel models ...
Lei Lei, Lei Lei, Yinuo Zhou, Lizhen Ye, Yanfang Yang   +4 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Sensory impairment reduces money sharing in the Dictator Game regardless of the recipient's sensory status.

PLoS ONE, 2020
Altruism varies as a function of minimal social cues. Sensory impaired individuals elicit more altruistic behaviors, at the same time being more prone to be exploited.
Anna Oleszkiewicz, Teresa Kupczyk
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source