Results 71 to 80 of about 195,092 (251)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hearing and vision impairment and social isolation over 8 years in community-dwelling older adults

BMC Public Health
Background Little is known about the long-term impact of hearing and vision impairment on social isolation. This study quantifies the association between hearing, vision, and concurrent hearing and vision impairment (dual sensory impairment) and social ...
Alison R. Huang, Thomas K. M. Cudjoe, George W. Rebok, Bonnielin K. Swenor, Jennifer A. Deal   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Common mental illness in people with sensory impairment: results from the 2014 adult psychiatric morbidity survey

BJPsych Open, 2019
BackgroundPeople with sensory impairments may be at increased risk of depression and anxiety but experience barriers to accessing treatment.AimsTo investigate whether people with sensory impairment have more depressive and anxiety symptoms than people ...
Natalie Shoham, Gemma Lewis, Sally McManus, Claudia Cooper   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Midlife sensory and motor functions improve long‐term predictions of cognitive decline and incidence of cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We aimed to assess whether midlife sensory and motor functions improve risk prediction of 10‐year cognitive decline and impairment when added to risk prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia ...
Carla R. Schubert, A. Alex Pinto, Adam J. Paulsen, Richard J. Chappell, Yanjun Chen, Corinne D. Engelman, Luigi Ferrucci, Laura M. Hancock, Sterling C. Johnson, Natascha Merten   +9 more
doaj   +1 more source

Televizyon Haberlerinde Erişilebilirlik Üzerine Bazı Gözlem ve Öneriler

Selçuk İletişim, 2020
Bu çalışmada televizyon haberlerinin duyusal engeli olan izleyiciler açısından erişilebilirlik düzeyi ele alınmıştır. 15 farklı kanala ait 20 haberden oluşan örneklem, nitel yöntemle çözümlenerek erişilebilirliğin görsel ve işitsel iletişim kanallarından
Mine Güven
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The impact of visual and hearing impairments on the risk of arthritis among middle-aged and older Chinese adults (2011–2015): the mediating role of depressive symptoms

BMC Public Health
Background To date, the mechanisms underlying the relationship between sensory impairment and new-onset arthritis remain inadequately understood. This study aims to investigate the mediating role of depressive symptoms in the longitudinal association ...
Chenyang Li, Shuai Ma, Ning Zhang, Jie Yuan, Tengbo Shi, Shanlin Tong, Ying Zhang   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source