Results 111 to 120 of about 397,035 (315)

Pre- and postsynaptic nanostructures increase in size and complexity after induction of long-term potentiation

iScience
Summary: Synapses, specialized contact sites between neurons, are the fundamental elements of neuronal information transfer. Synaptic plasticity involves changes in synaptic morphology and the number of neurotransmitter receptors, and is thought to ...
Valérie Clavet-Fournier, ChungKu Lee, Waja Wegner, Nils Brose, JeongSeop Rhee, Katrin I. Willig   +5 more
doaj   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Context familiarity is a third kind of episodic memory distinct from item familiarity and recollection

iScience
Summary: Episodic memory is accounted for with two processes: “familiarity” when generally recognizing an item and “recollection” when retrieving the full contextual details bound with the item.
Richard J. Addante, Evan Clise, Randall Waechter, Jesse Bengson, Daniel L. Drane, Jahdiel Perez-Caban   +5 more
doaj   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection

iScience
Summary: Neural representations for visual stimuli typically emerge with a bilateral distribution across occipitotemporal cortex (OTC). Pediatric patients undergoing unilateral OTC resection offer an opportunity to evaluate whether representations for ...
Michael C. Granovetter, Anne Margarette S. Maallo, Shouyu Ling, Sophia Robert, Erez Freud, Christina Patterson, Marlene Behrmann   +6 more
doaj   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation

iScience
Summary: Acute alcohol can have profound effects on the brain and behavior. Dorsal medial prefrontal cortex (dmPFC) function is especially sensitive to disruption from acute alcohol exposure.
Kathleen G. Bryant, David Swygart, Yuexi Yin, Meredith R. Bauer, Mitchell D. Morningstar, Nicholas M. Timme, William H. Barnett, Colleen E. McGonigle, Eric A. Engleman, Patrick L. Sheets, Christopher C. Lapish   +10 more
doaj   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Automated sleep staging from single-channel electroencephalogram using hybrid neural network with manual features and attention

iScience
Summary: Sleep staging is essential for evaluating sleep quality, diagnosing disorders, and creating personalized treatment plans. The convolutional and bidirectional long short-term memory hybrid neural network (CNN-BiLSTM) has shown promise in ...
Qingyun Wan, Yuyang Bo, Ying Zhang, Mufeng Li, Xiaoqiu Wang, Chuang Chen, Lanying Liu, Wenzhong Wu   +7 more
doaj   +1 more source