Results 41 to 50 of about 891,046 (227)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effects of Substituting Wheat with Waxy Barley Bran Flour on Physical Properties, Health Functionality, and Sensory Characteristics of Noodles

Foods
When waxy barley (WB) is milled, 40% of the weight is typically discarded as bran. To utilize WB bran resources and improve health functionality, flours prepared from inner bran (IB) and outer bran (OB) layers were used to substitute partially wheat all ...
Yoko Tsurunaga, Ayane Uno, Tetsuya Takahashi, Tsugumi Furuichi   +3 more
doaj   +1 more source

Supplemental vibrotactile feedback control of stabilization and reaching actions of the arm using limb state and position error encodings

Journal of NeuroEngineering and Rehabilitation, 2017
Background Deficits of kinesthesia (limb position and movement sensation) commonly limit sensorimotor function and its recovery after neuromotor injury.
Alexis R. Krueger, Psiche Giannoni, Valay Shah, Maura Casadio, Robert A. Scheidt   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sensory substitution

Definicja pojęcia: tekst omawia zjawisko substytucji sensorycznej. w pierwszej części rozdziału przedstawiono rozważania dotyczące definicji pojęcia, wykazano warunki konieczne dla wystąpienia substytucji oraz poddano analizie przykłady tego zjawiska ...
Wierzchoń, Michał
core   +1 more source

Sensory substitution devices and behavioural transference: a commentary on recent work from the lab of Amir Amedi

, 2018
Sensory substitution devices (SSDs) are most familiar from their use with subjects who are deficient in a target modality (e.g. congenitally blind subjects), but there is no doubt that the use and potential value of SSDs extend to persons without such ...
Brown, Derek, Derek Brown
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Production and quality evaluation of high fiber functional cupcake using watermelon [PDF]

Brazilian Journal of Biology
This study evaluated the effects of partially replacing wheat flour with watermelon peel powder (WPP) at substitution levels of 5%, 10%, 15%, and 20% on the quality characteristics of cupcakes. We conducted comprehensive analyses of chemical composition,
M. G. E. Gadallah, I. Ragab, W. E. Ahmed, Ammar AL Farga, R. M. Alhomaid   +4 more
doaj   +2 more sources