Results 91 to 100 of about 166,676,583 (294)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Solving the Klein–Gordon–Fock Equation Using Separation of Variables in the Light-Front Coordinates

Axioms
In this article, we present a methodological and systematic approach to solving the Klein–Gordon–Fock equation using the separation of variables method, with particular emphasis on its formulation in light-front coordinates.
Gislan Silveira Santos, Jorge Henrique de Oliveira Sales, Cássio Almeida Lima   +2 more
doaj   +1 more source

Fourier, Gegenbauer and Jacobi Expansions for a Power-Law Fundamental Solution of the Polyharmonic Equation and Polyspherical Addition Theorems

Symmetry, Integrability and Geometry: Methods and Applications, 2013
We develop complex Jacobi, Gegenbauer and Chebyshev polynomial expansions for the kernels associated with power-law fundamental solutions of the polyharmonic equation on d-dimensional Euclidean space.
Howard S. Cohl
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

How can we manage repairing a broken finite vibrating string? Solutions to the problem II

Journal of Optimization, Differential Equations and Their Applications
The current research deals with the IBVP (JODEA, 31 (2) (2023), 89 – 114) for the 1D homogeneous wave equation with discontinuous piece-wise constant coefficient posed to study three approaches to implement the transmission conditions (called ‘repairing’
Vladimir L. Borsch
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Is functional separation BT-style the answer? [PDF]

, 2008
This paper focuses on functional separation. After recounting the circumstances that culminated in the imposition of functional separation within the UK, the paper highlights the difficulties that have been encountered subsequent to the creation of ...
Whalley, J.L., Curwen, P.J.
core   +3 more sources

Solutions of Helmholtz and Schrödinger Equations with Side Condition and Nonregular Separation of Variables

Symmetry, Integrability and Geometry: Methods and Applications, 2012
Olver and Rosenau studied group-invariant solutions of (generally nonlinear) partial differential equations through the imposition of a side condition. We apply a similar idea to the special case of finite-dimensional Hamiltonian systems, namely Hamilton-
Philip Broadbridge, Claudia M. Chanu, Willard Miller Jr.   +2 more
doaj   +1 more source