Results 191 to 200 of about 169,356 (299)

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

Protocol for HIV-1 latency reversal using engineered bacteriophage T4 particles. [PDF]

STAR Protoc
Batra H, Rao VB.
europepmc   +1 more source

Continuous Purification of mRNA Produced by In Vitro Transcription Using High Performance Countercurrent Membrane Purification

Biotechnology and Bioengineering, Volume 123, Issue 9, Page 2303-2311, September 2026.
ABSTRACT Messenger ribonucleic acid (mRNA) therapeutics produced by in vitro transcription must be purified to remove residual enzymes and free nucleotides. This study examines the use of high‐performance countercurrent membrane purification (HPCMP) for the purification of mRNA therapeutics based on differences in the rate of diffusion across ...
Ziqiao Wang, Amin Javidanbardan, Ali Behboudi, Andrew L. Zydney   +3 more
wiley   +1 more source

Pacin, a novel bacteriocin from <i>Pseudomonas</i> strain 166, exhibits anti-MRSA activity with low toxicity and high therapeutic potential. [PDF]

Microbiol Spectr
Wang Y, Fu X, He Y, Ma Y, Meng X, Yang Y, Kong L, Guo H.   +7 more
europepmc   +1 more source

Differential expression of TKS4 isoforms and their role in cellular processes in breast cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
TKS4 isoforms are differentially expressed across human cell lines. TKS4L interacts with six novel SRC homology 3‐containing proteins, whereas no interactions were detected for TKS4b. SRC‐mediated phosphorylation promotes interactions of TKS4 with SH2 domains.
Serhii Kropyvko, Nazar Shevchuk, Olga Gubar, Kyrylo Lavrynenko, Yaroslav Nemesh, Denys Kozakov, Valentyn Polishchuk, Valentyna Kryklyva, Liubov Syvak, Nataliia Verovkina, Tetyana Gryaznova   +10 more
wiley   +1 more source

Purification of immunoglobulins using protein A-Sepharose.

, 1988
Hammond, J. B. W., Kruger, N. J.
core  

FOXO6 inhibits SMURF2‐mediated ubiquitination and degradation of NR4A1 to promote retinal pigment epithelial cell ferroptosis in diabetic retinopathy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
FOXO6 suppresses the transcriptional expression of SMURF2, thereby limiting the ubiquitination and degradation of NR4A1. Stabilized NR4A1 promotes ferroptosis in RPE cells, contributing to the progression of diabetic retinopathy. Abstract Diabetic retinopathy (DR) is the main cause of vision loss, with retinal pigment epithelial (RPE) cell dysfunction ...
Qiao Chen, Bo Su, Ke Xu, Liang Li, Changzheng Chen   +4 more
wiley   +1 more source

FX-Cell: a method for single-cell RNA sequencing on difficult-to-digest and cryopreserved plant samples. [PDF]

Nat Methods
Ming X, Wan MC, Zhang ZD, Xue HC, Wu YQ, Xu ZG, Lian H, Yuan MT, Mai YX, Hu YX, Liu K, Gao J, Shao QL, Marchant DB, Nelms B, Walbot V, Wang JW.   +16 more
europepmc   +1 more source

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CDO1 is a tumour suppressor in gastric cancer that directly binds PI3K p85α, disrupting p85α–p110α dimerization to inhibit the PI3K/AKT–THBS1 axis. Decitabine epigenetically restores CDO1 expression and exerts CDO1‐dependent anti‐tumour activity, synergizing with 5‐FU. Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1)
Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen   +6 more
wiley   +1 more source

Stable and Specific Multiprotein Complexes with High Molecular Masses in Different Organs of the Sea Cucumber <i>Eupentacta fraudatrix</i>. [PDF]

Int J Mol Sci
Soboleva SE, Dmitrenok PS, Nevinsky GA.
europepmc   +1 more source