Results 201 to 210 of about 169,356 (299)

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

Comparison of the antibacterial properties of peptides from the hepatopancreas of red king crab and snow crab and development of an approach for red king crab peptide isolation from the hepatopancreas. [PDF]

PeerJ
Molchanov V, Yunusova A, Kazantseva O, Yegorov A, Lukin A, Timchenko A, Novikov V, Novojilov N, Timchenko M.   +8 more
europepmc   +1 more source

Structural Characteristics and Immunoregulatory Effects of Colla Corii Asini Peptides with Iron‐Chelating Capacity

Food Frontiers, Volume 7, Issue 5, September 2026.
Ejiao peptides were fractionated to iron‐chelating F2 (enriched in E‐Xn‐P motif), which restored immune function in CTX‐induced immunosuppressed mice via synergistic regulation of immunity and iron homeostasis. ABSTRACT Iron homeostasis is closely related to immune function, yet the structural basis of food‐derived peptides that modulate this iron ...
Qing‐Tao Zhan, Zi‐Wei Zhao, Jian‐Hang Cai, Xue‐Mei Ge, Shuang‐Di Chen, Xue Tang, Xue‐Ying Ma, Liu‐Ping Fan, Issoufou Amadou, Xiang‐Rong Cheng   +9 more
wiley   +1 more source

Plant chloroplasts enable high-yield and cost-effective production of the engineered bacterial enzyme CueO-MacHis as a technical protein via transient expression in <i>Nicotiana benthamiana</i>. [PDF]

Front Plant Sci
Nausch H, Bernau CR, Scheffler D, Schuphan JI.   +3 more
europepmc   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, Volume 3, Issue 3, September 2026.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Protocol for integrated ubiquitination analysis of in vitro E3 ligase-DUB regulation and in vivo ubiquitin chain linkage characterization. [PDF]

STAR Protoc
Mennerich D, Vela-Rodriguez C, Lehtiö L, Kietzmann T.   +3 more
europepmc   +1 more source

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı   +3 more
wiley   +1 more source

Synthesis of <i>Arapaima gigas</i> Growth Hormone (ag-GH) in HEK 293 Cells: Its Purification and Characterization via In Vivo Bioassay in Dwarf "Little" Mice. [PDF]

Molecules
Lima ER, Melo JCR, Bezerra FM, Suzuki MF, Nunes AP, Sevilhano TCDA, Oliveira JE, Garcez R, Torati LS, Magalhães GS, Peroni CN, Bartolini P.   +11 more
europepmc   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

CAST controls presynaptic sequestration of Rab6 in neurons. [PDF]

Mol Brain
Hida Y, Shimada A, Kim YJ, Kato-Murayama M, Shirouzu M, Ohtsuka T.   +5 more
europepmc   +1 more source