Results 211 to 220 of about 169,356 (299)

Engineering Piezo1‐Mediated Calcium Signalling for Enhanced Extracellular Vesicle Biogenesis and Cargo Loading

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Cell‐derived extracellular vesicles (EVs) are promising nanocarriers for therapeutic delivery platforms owing to their biocompatibility and capacity to protect and efficiently transport bioactive molecules. However, EV‐based therapeutics remain constrained by inefficient cargo loading and low production yields, which limit scalable ...
Najla A. Saleh, Rozita Shafiq, Amanda P. Cicerone, Sadhana Kilangodi, Hayden Hartwig, George I. Mias, Guangqing Lu, Jun R. Huh, Weiping Li, Cheri X. Deng, Masamitsu Kanada   +10 more
wiley   +1 more source

Engineering of Glioblastoma-Derived Biomimetic Vesicles and Their Structural and Molecular Features. [PDF]

Adv Healthc Mater
Hernández-Lobato N, Abumanhal-Masarweh H, de Cabo M, Guerra P, Hadjidemetriou M, Lozano N, Kostarelos K.   +6 more
europepmc   +1 more source

Scalable and Controlled Production of Microalgae‐derived Extracellular Vesicles Using a Differential Tangential Flow Filtration Protocol

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
This work presents a robust project design for the scalable production of extracellular vesicles, focusing on nanoalgosomes derived from microalgae. Careful parameter optimization within a filtration‐based process ensures consistent isolation while preserving the structural and functional integrity of the vesicles.
Angela Paterna, Estella Rao, Paola Gargano, Sabrina Picciotto, Giorgia Adamo, Samuele Raccosta, Antonella Bongiovanni, Mauro Manno   +7 more
wiley   +1 more source

Historical Insights Into the Purification of Polyphenol Oxidase From Plants. [PDF]

Food Sci Nutr
Vazquez-Lima CG, Quintana-Quirino M, Bravo AL, López-Simeon R, Nájera H.   +4 more
europepmc   +1 more source

Sequence‐encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional diversity but also permits
Harshita Sawdekar, Julien Mignon, Frank Gondelaud, Anuja Walimbe, Samrat Mukhopadhyay, Joseph Chamieh, Sonia Longhi   +6 more
wiley   +1 more source

Protocol for measuring the caspase-8 activity at the DED filaments in adherent cells. [PDF]

STAR Protoc
König C, Lavrik IN.
europepmc   +1 more source

Molecular logics in dual sensor regulation of diguanylate cyclase activity—Phosphorylation OR blue‐light activation

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Maximilian Fuchs, Andreas Winkler
wiley   +1 more source

Lactate dehydrogenase A exhibits sorbitol/fructose-related catalytic activity and contributes to polyol pathway metabolism in tumor cells. [PDF]

Front Endocrinol (Lausanne)
Feng S, Hu Z, Tong H, Zhang H.
europepmc   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 9, Page 1610-1627, September 2026.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

A direct interaction of JAM-C with the tight junction scaffold protein ZO-2. [PDF]

Sci Rep
Schulte A, Schwietzer MF, Brinkmann F, Teuber V, Citi S, Furuse M, Aurrand-Lions M, Ebnet K.   +7 more
europepmc   +1 more source