Results 231 to 240 of about 169,356 (299)

AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ‐Secretase Assembly

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
AHA1 regulates Aβ production through dual mechanisms. AHA1 promotes APP abundance through mechanisms that are at least partially independent of Hsp90 interaction, while cooperating with Hsp90 to regulate APH1/NCT pre‐complex formation, γ‐secretase assembly, and γ‐secretase activity. These coordinated mechanisms contribute to increased Aβ generation and
Arshad Ali Noorani, Sadequl Islam, Emma Filip, Kevin Catalfano, Shravan Paswan, Vaishnavi Nagarajan, Heather M. Wilkins, Brian S. J. Blagg, Kun Zou, Michael S. Wolfe   +9 more
wiley   +1 more source

A novel and rapid method to purify the human complement opsonin C3b from human plasma. [PDF]

Front Immunol
Sichau J, Schmidt CQ.
europepmc   +1 more source

DrdR Negatively Modulates the Expression of Flagellar Genes via Interaction With FleQ in Xanthomonas campestris

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
Upon activation by an unknown signal, DrdR targets FleQ, inhibiting its ATPase activity and DNA binding ability. This blocks FleQ from activating the transcription of flagellar genes, downregulating gene expression and suppressing swimming motility. ABSTRACT Response regulators (RRs) of two‐component signalling systems (TCSs) containing tandem receiver
Pei‐Dong Ren, Jie Zheng, Hong‐Ying Sun, Yan‐Hua Qi, Ji‐Liang Tang, Rui‐Fang Li, Guang‐Tao Lu   +6 more
wiley   +1 more source

Selective removal of soluble FLT-1 using a high-affinity DNA aptamer for potential apheresis treatment of preeclampsia. [PDF]

Sci Rep
Owari K, Piao H, Hori M, Futami K.
europepmc   +1 more source

The pathogenic effector PHYL1JWB interacts with ZjCURT1A to mediate jujube witches' broom‐induced photosynthesis impairment of jujube trees

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Photosynthesis impairment and the accompanying leaf yellowing represent a prominent and physiologically critical symptom of phytoplasma infection. However, the underlying molecular mechanisms remain poorly understood. In this study, we identified the Jujube Witches' Broom pathogenic effector PHYL1JWB, which was previously reported to induce ...
Fangfang Huang, Changfeng Ai, Chong Yang, Jie Feng, Meng Yang, Li Dai, Chaoling Xue, Hongtai Li, Jiaxue Cui, Xiangjie Qu, Jin Zhao, Mengjun Liu, Xuan Zhao, Zhiguo Liu   +13 more
wiley   +1 more source

The Plasmodium berghei merozoite protein PbGAC is critically involved in erythrocyte binding during invasion. [PDF]

Parasit Vectors
Gao J, Jiang N, Zhang Y, Chen R, Feng Y, Sang X, Chen Q.   +6 more
europepmc   +1 more source

Structural and Biophysical Characterization of C‐Glycosylic 1,2‐Thiodisaccharides Reveals Determinants of Selective Binding to Galectin‐7 and Galectin‐8N

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
The molecular basis of galectin recognition by C‐glycosylic 1,2‐thiodisaccharides is revealed. While Gly‐1 provides a conserved affinity driving interaction, Gly‐2 governs isoform selectivity through contacts with variable CRD regions. Unique galectin‐8N residues are identified as attractive handles for the development of next‐generation selective ...
Anastasia S. Tsagkarakou, Anastassia L. Kantsadi, Vasiliki I. Theodoridou, Nikolaos Veliotis, László Lázár, János József, László Juhász, George Kontopidis, Hakon Leffler, Ulf J. Nilsson, László Somsák, Demetres D. Leonidas   +11 more
wiley   +1 more source

Quantitative LC-MS/MS profiling reveals aberrant chondroitin sulfate in Alzheimer's disease. [PDF]

Commun Biol
Xu Y, Wang H, Wang Z, Zhang J, Stancanelli E, Xu Q, Hou Y, Wang C, Zhang P, Gearing M, Liu J.   +10 more
europepmc   +1 more source

A Comparative Biochemical Study of Oleate Hydratases

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Four oleate hydratases (Ohys) from diverse homologous families (HFams) were characterized side‐by‐side in terms of expression levels, oligomeric state, flavin adenine dinucleotide (FAD) affinity, thermostability, and activity. A general favorable effect of the reduction of FAD to FADH2 for Ohy activity was demonstrated, with (R)‐10‐hydroxystearic acid (
Maxim van Delft, Alejandro Gran‐Scheuch, Ulf Hanefeld, Peter‐Leon Hagedoorn   +3 more
wiley   +1 more source

Degradation and ring-opening polymerization of poly(ε-caprolactone) by a novel enzyme from <i>Pseudomonas</i> sp. DS0801. [PDF]

iScience
Di Y, Luan W, Sun L, Qi J, Xia H, Li F, Zhai N.   +6 more
europepmc   +1 more source