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Biomarkers in sepsis [PDF]

Current Opinion in Pulmonary Medicine, 2013
This review discusses the current developments in biomarkers for sepsis.With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely revolutionize the management of sepsis.
Singer, M
openaire   +6 more sources

Detecting Respiratory Pathogens for Diagnosing Lower Respiratory Tract Infections at the Point of Care: Challenges and Opportunities

Biosensors
Lower respiratory tract infections (LRTIs) are a leading cause of mortality worldwide, claiming millions of lives each year and imposing significant healthcare costs.
Francisco M. Bouzada, Bartomeu Mestre, Andreu Vaquer, Sofía Tejada, Roberto de la Rica   +4 more
doaj   +1 more source

Bioreactance reliably detects preload responsiveness by the end-expiratory occlusion test when averaging and refresh times are shortened

Annals of Intensive Care, 2021
Background The end-expiratory occlusion (EEXPO) test detects preload responsiveness, but it is 15 s long and induces small changes in cardiac index (CI).
Francesco Gavelli, Alexandra Beurton, Jean-Louis Teboul, Nello De Vita, Danila Azzolina, Rui Shi, Arthur Pavot, Xavier Monnet   +7 more
doaj   +1 more source

DENTAL SEPSIS [PDF]

BMJ, 1914
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openaire   +4 more sources

Impact of interventions to reduce nosocomial transmission of SARS-CoV-2 in English NHS Trusts: a computational modelling study

BMC Infectious Diseases
Background Prior to September 2021, 55,000–90,000 hospital inpatients in England were identified as having a potentially nosocomial SARS-CoV-2 infection. This includes cases that were likely missed due to pauci- or asymptomatic infection.
Stephanie Evans, James Stimson, Diane Pople, Peter J White, Mark H Wilcox, Julie V Robotham   +5 more
doaj   +1 more source

The Intestinal Microbiome after Traumatic Injury

Microorganisms, 2023
The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have ...
Jennifer A. Munley, Stacey L. Kirkpatrick, Gwendolyn S. Gillies, Letitia E. Bible, Philip A. Efron, Ravinder Nagpal, Alicia M. Mohr   +6 more
doaj   +1 more source

Epigenetics of Sepsis

Critical Care Medicine, 2020
Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term “epigenetics” refers to regulatory mechanisms that control gene expression but are not related to ...
Pedro Castelo-Branco, Alexandra Binnie, Claudia C. dos Santos, Claudia C. dos Santos, Pingzhao Hu, Gabriela Carrasqueiro, Jennifer L Y Tsang   +6 more
openaire   +4 more sources

A gain-of-function NLRP3 3′-UTR polymorphism causes miR-146a-mediated suppression of NLRP3 expression and confers protection against sepsis progression

Scientific Reports, 2021
Nucleotide-binding domain and leucine-rich repeat (LRR)-containing family protein 3 (NLRP3) regulated the maturation of inflammation-related cytokines by forming NLRP3 inflammasome, which plays pivotal roles in sepsis pathogenesis.
Furong Lu, Hongpeng Chen, Yuan Hong, Yao Lin, Lizhen Liu, Ning Wei, Qinyan Wu, Shuanglin Liao, Shuai Yang, Junbing He, Yiming Shao   +10 more
doaj   +1 more source

Innate immune training in the neonatal response to sepsis

Molecular Medicine
Neonates, especially those born prematurely, are highly vulnerable to infection-induced mortality. Numerous observational and immunological studies in newborns have shown that live attenuated vaccines have beneficial, non-specific effects (NSEs) against ...
Jaimar C. Rincon, Dayuan Wang, Valerie E. Polcz, Evan L. Barrios, Marvin L. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, Feifei Xiao, Philip A. Efron, Lyle L. Moldawer, Guoshuai Cai, Shawn D. Larson   +12 more
doaj   +1 more source

Sepsis

, 2014
The management of the child with sepsis represents the sine qua non of pediatric critical care medicine. Overwhelming sepsis and septic shock often manifest with concurrent derangements of cardiovascular function, intravascular volume status, respiratory function, immune regulation, renal function, coagulation, hepatic function, and metabolic function –
Wynn, James L., Hazelzet, Jan A., Shanley, Thomas P., Wong, Hector R., Wheeler, Derek S.   +4 more
openaire   +1 more source