Results 91 to 100 of about 673,315 (318)

Microneedles at the Forefront of Next Generation Theranostics

open access: yesAdvanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang   +8 more
wiley   +1 more source

Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease) [PDF]

open access: yes, 2018
Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic diseases(hypertension,dyslipidaemia,diabetes mellitus,chronic kidney disease,cardiovascular disease ...
arxiv   +1 more source

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

open access: yesNew England Journal of Medicine, 2017
BACKGROUND In 2013, New York began requiring hospitals to follow protocols for the early identification and treatment of sepsis. However, there is controversy about whether more rapid treatment of sepsis improves outcomes in patients.
C. Seymour   +9 more
semanticscholar   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu   +11 more
wiley   +1 more source

Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach

open access: yesBMC Bioinformatics, 2019
Background Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the underlying regulatory processes are only partly understood. Results We assembled regulator
Alexandra M. Poos   +6 more
doaj   +1 more source

Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas

open access: yesAdvanced Science, EarlyView.
A multi‐functional shear‐thinning hydrogel is engineered to treat enterocutaneous fistulas. This hydrogel can resist external pressures allowing it to remain within the fistula tract and is shown to have significant antimicrobial, pro‐healing, and anti‐inflammatory properties, which were validated in in vitro and in vivo experiments.
Jinjoo Kim   +6 more
wiley   +1 more source

Cost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia

open access: yesAmerican Journal of Hematology, Volume 98, Issue 1, Page 122-130, January 2023., 2023
Abstract Major options for second‐line therapy in adults with chronic immune thrombocytopenia (ITP) include splenectomy, rituximab, and thrombopoietin receptor agonists (TRAs). The American Society of Hematology guidelines recommend rituximab over splenectomy, TRAs over rituximab, and splenectomy or TRAs while noting a lack of evidence on the cost ...
George Goshua   +5 more
wiley   +1 more source

Ventriculo-arterial (VA) coupling and fQRS as new selection criteria for primary prevention ICD placement

open access: yesIntensive Care Medicine Experimental
For decades, left ventricular ejection fraction (LVEF 
Nathan Engstrom   +3 more
doaj   +1 more source

Dimethyl Itaconate Alleviates Escherichia coli‐Induced Endometritis Through the Guanosine‐CXCL14 Axis via Increasing the Abundance of norank_f_Muribaculaceae

open access: yesAdvanced Science, EarlyView.
The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He   +6 more
wiley   +1 more source

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