Sesamin attenuates intestinal injury in sepsis via the HMGB1/TLR4/IL-33 signalling pathway
Pharmaceutical Biology, 2020 Context Sepsis is currently one of the leading causes of death in intensive care units (ICUs). Sesamin was previously reported to inhibit inflammation. However, no studies have revealed the impact of sesamin on sepsis.
Zhi-Ling Li +5 more
doaj +1 more source
Epidemiology of intensive care unit-acquired sepsis in Italy: results of the SPIN-UTI network [PDF]
, 2018 BACKGROUND: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units ...
Agodi A +15 more
core +1 more source
Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]
, 2012 Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Barnett, A. H. +11 more
core +3 more sources
Lactate concentration gradient from right atrium to pulmonary artery: a commentary [PDF]
, 2005 Inadequate myocardial performance is a common complication of severe sepsis. Studies in humans strongly argue against a decrease in coronary blood flow in the pathogenesis of this sepsis-induced cardiac injury.
Creteur, Jacques
core +2 more sources
PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]
, 2019 Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G +10 more
core +2 more sources
Composed endotypes to guide antibiotic discontinuation in sepsis
Critical Care, 2019 Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the emergence of MDR.
Jesus F. Bermejo-Martin +4 more
doaj +1 more source
A snapshot of compliance with the sepsis six care bundle in two acute hospitals in the West Midlands, UK [PDF]
, 2019 The sepsis six care bundle has been adopted by hospitals in England and Wales for the management of patients with sepsis, with the aim of increasing survival when all elements of the bundle are achieved.
Frankling, Catriona +6 more
core +1 more source
Critical Care, 2018 Background This study aimed to evaluate the accuracy of procalcitonin (PCT) serum concentrations to diagnose Gram-negative bacteremia and the association of PCT serum concentrations with more specific pathogens and the focus of infection.
Daniel O. Thomas-Rüddel +6 more
doaj +1 more source
Identifying which septic patients have increased mortality risk using severity scores:a cohort study [PDF]
, 2014 Background: Early aggressive therapy can reduce the mortality associated with severe sepsis but this relies on prompt recognition, which is hindered by variation among published severity criteria. Our aim was to test the performance of different severity
Davey, Peter G +5 more
core +4 more sources