Results 41 to 50 of about 1,046,938 (380)
JAMA Internal Medicine, 2021 Importance The Epic Sepsis Model (ESM), a proprietary sepsis prediction model, is implemented at hundreds of US hospitals. The ESM's ability to identify patients with sepsis has not been adequately evaluated despite widespread use.
Andrew Wong +11 more
semanticscholar +1 more source
Glucocorticoids in Sepsis: To Be or Not to Be
Frontiers in Immunology, 2020 Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis.
Jolien Vandewalle +3 more
openaire +4 more sources
BMC Public Health, 2021 Background Sepsis is a substantial health care burden. Data on regional variation in sepsis incidence in Germany and any possible associations with regional socioeconomic deprivation and health care capacity is lacking.
Norman Rose +6 more
doaj +1 more source
Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis [PDF]
, 2014 Introduction: The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis.
Bergmann A +5 more
core +1 more source
BioMed Research International, 2014 Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process.
Henriquez-Camacho, Cesar, Losa, Juan
openaire +4 more sources
The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]
, 2018 Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos +15 more
core +1 more source
Cell Death and Differentiation, 2021 High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Kun Yang +10 more
semanticscholar +1 more source
Kidney International, 2000 The pathophysiology of sepsis offers a highly complicated scenario. In sepsis, endotoxin or other gram-positive-derived products induce a complex and dynamic cellular response, giving rise to several mediators known to be relevant in the pathogenesis of septic shock such as specific mediators, substances responsible for up- or down-regulation of ...
Ronco C +7 more
openaire +4 more sources
Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. [PDF]
, 2020 Death due to sepsis remains a persistent threat to critically ill patients confined to the intensive care unit and is characterized by colonization with multi-drug-resistant healthcare-associated pathogens.
Alverdy, John C +24 more
core
Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial. [PDF]
, 2017 IntroductionSeveral methods have been developed to electronically monitor patients for severe sepsis, but few provide predictive capabilities to enable early intervention; furthermore, no severe sepsis prediction systems have been previously validated in
Barton, Christopher W +4 more
core +2 more sources