Results 41 to 50 of about 838,377 (353)

Identifying which septic patients have increased mortality risk using severity scores:a cohort study [PDF]

, 2014
Background: Early aggressive therapy can reduce the mortality associated with severe sepsis but this relies on prompt recognition, which is hindered by variation among published severity criteria. Our aim was to test the performance of different severity
Davey, Peter G, Evans, Josie Mm, Guthrie, Bruce, Marwick, Charis A, McLeod, Shaun R, Pringle, Jan Ec   +5 more
core   +4 more sources

Digital PCR applications for the diagnosis and management of infection in critical care medicine

Critical Care, 2022
Infection (either community acquired or nosocomial) is a major cause of morbidity and mortality in critical care medicine. Sepsis is present in up to 30% of all ICU patients.
Irene Merino, Amanda de la Fuente, Marta Domínguez-Gil, José María Eiros, Ana P. Tedim, Jesús F. Bermejo-Martín   +5 more
doaj   +1 more source

Biomarkers for Sepsis [PDF]

BioMed Research International, 2014
Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process.
Henriquez-Camacho, Cesar, Losa, Juan
openaire   +4 more sources

Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis [PDF]

, 2014
Introduction: The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis.
Bergmann A, DI SOMMA, Salvatore, Magrini L, Maisel AS, MARINO, Rossella, Struck J   +5 more
core   +1 more source

Association between sepsis incidence and regional socioeconomic deprivation and health care capacity in Germany – an ecological study

BMC Public Health, 2021
Background Sepsis is a substantial health care burden. Data on regional variation in sepsis incidence in Germany and any possible associations with regional socioeconomic deprivation and health care capacity is lacking.
Norman Rose, Claudia Matthäus-Krämer, Daniel Schwarzkopf, André Scherag, Sebastian Born, Konrad Reinhart, Carolin Fleischmann-Struzek   +6 more
doaj   +1 more source

Sphingolipidomics in Translational Sepsis Research–Biomedical Considerations and Perspectives

Frontiers in Medicine, 2021
Scientific Background: Sphingolipids are a highly diverse group of lipids with respect to physicochemical properties controlling either structure, distribution, or function, all of them regulating cellular response in health and disease.
Ralf A. Claus, Markus H. Graeler, Markus H. Graeler, Markus H. Graeler   +3 more
doaj   +1 more source

Glucocorticoids in Sepsis: To Be or Not to Be

Frontiers in Immunology, 2020
Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis.
Jolien Vandewalle, Jolien Vandewalle, Claude Libert, Claude Libert   +3 more
openaire   +4 more sources

Adsorption in sepsis [PDF]

Kidney International, 2000
The pathophysiology of sepsis offers a highly complicated scenario. In sepsis, endotoxin or other gram-positive-derived products induce a complex and dynamic cellular response, giving rise to several mediators known to be relevant in the pathogenesis of septic shock such as specific mediators, substances responsible for up- or down-regulation of ...
Ronco C, Brendolan A, Dan M, Piccinni P, Bellomo R, De Nitti C, Inguaggiato P, Tetta C   +7 more
openaire   +3 more sources

The atypical chemokine receptor ACKR2 is protective against sepsis [PDF]

, 2018
Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection and chemokines play a key role in recruiting neutrophils.
Alves-Filho, José Carlos, Amaral, Flávio Almeida, Borges, Vanessa, Castanheira, Fernanda Vargas E. Silva, Cunha, Fernando Queiroz, Cunha, Thiago Mattar, Donate, Paula Barbim, Graham, Gerard J., Kanashiro, Alexandre, Liew, Foo Y., Melo, Paulo Henrique, Pallas, Kenneth, Ramalho, Fernando Silva, Russo, Remo Castro, Sônego, Fabiane, Teixeira, Mauro Martins   +15 more
core   +1 more source

Evaluation of updated sepsis scoring systems and systemic inflammatory response syndrome criteria and their association with sepsis in equine neonates [PDF]

, 2018
BackgroundThe original equine sepsis score provided a method of identifying foals with sepsis. New variables associated with sepsis have been evaluated, but the sepsis score has not been updated.ObjectivesTo evaluate the sensitivity and specificity of 2 ...
Bates, Bone, Bone, Book, Borchers, Borchers, Brewer, Brewer, Castagnetti, Cohen, Corley, Corley, Dellinger, Dembek, Giguere, Goldstein, Hackett, Hanley, Hollis, Hytychová, Jaimes, Marsh, Muckart, Pusterla, Rangel-Frausto, Rohrbach, Russell, Singer, Toth, Troger, Venkatesh, Vincent, Weber, Weinstein, Wilson, Wong, Zabrecky   +36 more
core   +1 more source