Results 41 to 50 of about 1,008,809 (397)

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

Intensive Care Medicine, 2013
ObjectiveTo provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008.DesignA consensus committee of 68 international experts representing 30 international organizations was ...
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno, The Surviving Sepsis Campaign Guidelines Committee inc Subgroup   +23 more
semanticscholar   +1 more source

External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients.

JAMA Internal Medicine, 2021
Importance The Epic Sepsis Model (ESM), a proprietary sepsis prediction model, is implemented at hundreds of US hospitals. The ESM's ability to identify patients with sepsis has not been adequately evaluated despite widespread use.
Andrew Wong, E. Otles, J. Donnelly, A. Krumm, J. McCullough, Olivia DeTroyer-Cooley, J. Pestrue, Marie Phillips, Judy Konye, C. Penoza, Muhammad Ghous, Karandeep Singh   +11 more
semanticscholar   +1 more source

Biomarkers for Sepsis [PDF]

BioMed Research International, 2014
Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process.
Henriquez-Camacho, Cesar, Losa, Juan
openaire   +4 more sources

Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis

Critical Care Explorations, 2021
Objectives:. Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis.
Anuradha Ramoji, PhD, Daniel Thomas-Rüddel, MD, Oleg Ryabchykov, PhD, Michael Bauer, MD, Natalie Arend, MSc, Evangelos J. Giamarellos-Bourboulis, MD, Jesper Eugen-Olsen, PhD, Michael Kiehntopf, MD, Thomas Bocklitz, PhD, Jürgen Popp, PhD, Frank Bloos, MD, PhD, Ute Neugebauer, PhD   +11 more
doaj   +1 more source

Efficacy and safety of recombinant human activated protein C for severe sepsis.

New England Journal of Medicine, 2001
BACKGROUND Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties.
G. R. Bernard, J. L. Vincent, P. Laterre, S. LaRosa, J. Dhainaut, A. Lopez-Rodriguez, J. Steingrub, G. E. Garber, J. Helterbrand, E. W. Ely, C. J. Fisher   +10 more
semanticscholar   +1 more source

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

Cell Death and Differentiation, 2021
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Kun Yang, Min Fan, Xiaohui Wang, Jingjing Xu, Yana Wang, Fei Tu, P. Gill, T. Ha, Li Liu, David L. Williams, Chuanful Li   +10 more
semanticscholar   +1 more source

DENTAL SEPSIS [PDF]

BMJ, 1914
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openaire   +4 more sources

Association between sepsis incidence and regional socioeconomic deprivation and health care capacity in Germany – an ecological study

BMC Public Health, 2021
Background Sepsis is a substantial health care burden. Data on regional variation in sepsis incidence in Germany and any possible associations with regional socioeconomic deprivation and health care capacity is lacking.
Norman Rose, Claudia Matthäus-Krämer, Daniel Schwarzkopf, André Scherag, Sebastian Born, Konrad Reinhart, Carolin Fleischmann-Struzek   +6 more
doaj   +1 more source

mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol

BMJ Open, 2022
Introduction Maternal sepsis remains a leading cause of death in pregnancy. Physiological adaptations to pregnancy obscure early signs of sepsis and can result in delays in recognition and treatment.
Daniel White, Sarah Bell, Shaun Oram, Robert Andrews, Mallinath Chakraborty, Sarah Edkins, W John Watkins, Patrícia R S Rodrigues, Angela Strang, Summia Zaher, Simran Sharma, Luke C Davies, Linda Moet, James E McLaren, Valerie B O’Donnell, Peter Ghazal, Edward Parkinson, Nicos Angelopoulos, Freya Shepherd, Kate Megan Megan Davies, Kate Siddall, Vikki Keeping, Kathryn Simpson, Federica Faggian, Maryanne Bray, Claire Bertorelli, Rachel E Collis, Mario Labeta   +27 more
doaj   +1 more source

Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study. [PDF]

, 2019
BACKGROUND: Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis is different from other emergent conditions including acute coronary syndrome, stroke, or ...
Abe, T, Fujishima, S, Gando, S, Hagiwara, A, Hifumi, T, Ikeda, H, Iriyama, H, JAAM FORECAST group, Komori, A, Kotani, J, Kushimoto, S, Masuno, T, Mayumi, T, Naito, T, Nakada, T-A, Ogura, H, Okamoto, K, Otomo, Y, Phillips, GS, Rhodes, A, Saitoh, D, Sakamoto, Y, Sasaki, J, Shiino, Y, Shiraishi, A, Shiraishi, S-I, Sugiyama, T, Takeyama, N, Takuma, K, Tarui, T, Tokuda, Y, Tsuruta, R, Ueyama, M, Umemura, Y, Yamakawa, K, Yamashita, N   +35 more
core   +1 more source