Hyperchloraemia in sepsis [PDF]
Chloride represents-quantitatively-the most prevalent, negatively charged, strong plasma electrolyte. Control of chloride concentration is a probable major mechanism for regulating the body's acid-base balance and for maintaining homeostasis of the entire internal environment. The difference between the concentrations of chloride and sodium constitutes
Filis, C.+2 more
openaire +4 more sources
ALRt: An Active Learning Framework for Irregularly Sampled Temporal Data [PDF]
Sepsis is a deadly condition affecting many patients in the hospital. Recent studies have shown that patients diagnosed with sepsis have significant mortality and morbidity, resulting from the body's dysfunctional host response to infection. Clinicians often rely on the use of Sequential Organ Failure Assessment (SOFA), Systemic Inflammatory Response ...
arxiv
Temporal Trends in Incidence, Sepsis-Related Mortality, and Hospital-Based Acute Care After Sepsis. [PDF]
OBJECTIVES: A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and ...
Bowles, Kathryn H.+6 more
core +1 more source
Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Ertel, Wolfgang+6 more
core +1 more source
Sepsis Education and Training in Medical School [PDF]
Purpose: According to the National Institutes of Health, severe sepsis strikes more than one million Americans every year. Despite the extensive research that has gone into creating the different risk stratification tools for sepsis, there is still a ...
Gaieski, MD, David F.+2 more
core +1 more source
Identifying which septic patients have increased mortality risk using severity scores:a cohort study [PDF]
Background: Early aggressive therapy can reduce the mortality associated with severe sepsis but this relies on prompt recognition, which is hindered by variation among published severity criteria. Our aim was to test the performance of different severity
Davey, Peter G+5 more
core +3 more sources
Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues.
Guohao Xie+3 more
openaire +2 more sources
Sepsis is a highly complex disease caused by a deregulated host’s response to infection [...]
Luisa Agnello, Marcello Ciaccio
openaire +4 more sources
Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis [PDF]
Introduction: The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis.
Bergmann A+5 more
core +1 more source
Predicting sepsis in multi-site, multi-national intensive care cohorts using deep learning [PDF]
Despite decades of clinical research, sepsis remains a global public health crisis with high mortality, and morbidity. Currently, when sepsis is detected and the underlying pathogen is identified, organ damage may have already progressed to irreversible stages. Effective sepsis management is therefore highly time-sensitive.
arxiv