Results 51 to 60 of about 875,517 (356)

Circulating NETs enable early identification of thrombotic risk in sepsis at emergency care onset

Frontiers in Immunology
IntroductionSepsis involves a dysregulated host response to infection and is frequently complicated by coagulopathy, contributing to organ dysfunction and mortality.
Sofia Tejada, Antonio Clemente, Antonio Clemente, Antonia Socias, Antonia Socias, Maria Aranda, Maria Aranda, Alberto del Castillo, Alberto del Castillo, Joana Mena, Joana Mena, Joana Mª Ribas, Joana Mª Ribas, Luisa Martín, Luisa Martín, Karla Milagritos Llerena, Karla Milagritos Llerena, María Magdalena Arellano, María Magdalena Arellano, Miguel Agudo, Roberto de la Rica, Roberto de la Rica, Marcio Borges, Marcio Borges   +23 more
doaj   +1 more source

Tricuspid Annular Plane of Systolic Excursion for the Evaluation of Patients with Severe Sepsis and Septic Shock [PDF]

, 2020
Introduction: Sepsis is a systemic infection that can rapidly progress into multi organ failure and shock if left untreated. Previous studies have demonstrated the utility of point of care ultrasound (POCUS) in the evaluation of patients with sepsis ...
Ali, Qumber, Fischetti, Chanel, Fox, John C., Lahham, Shadi, Lee, Clifton, Moeller, John, Saadat, Soheil, Thompson, Maxwell   +7 more
core  

Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats [PDF]

, 2014
Copyright @ 2013 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.Obesity is a risk factor for sepsis morbidity and mortality, whereas the hypothalamic-pituitary-adrenal (HPA) axis plays a protective role in ...
Ahima, ANDREIS, Arabi, Besedovsky, Blackwell, Bone, Bornstein, Carlson, Christopher D John, Clark, Connor, Costa, Csontos, Elenkov, Elmquist, GAILLARD, Heiman, Heuer, Hu, Huang, Jennifer A Parker, John, Julia C Buckingham, Kevin G Murphy, Kurt, Maffei, Mohn, Nishiyama, Ott, Pournajafi Nazarloo, Raber, Reyes, RIVIER, Rodr  guez-Wilhelmi, Saadia Basharat, Stephen R Bloom, Takao, Takemura, Vachharajani, Yousef, Zamorano   +40 more
core   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Primer Consenso Colombiano en Sepsis

Revista Colombiana de Cirugía, 2006
La sepsis, sepsis severa y el choque séptico tienen una incidencia alta y conllevan a una alta mortalidad, morbilidad y costos. Es por esto que la AMCI y la ACIN decidieron realizar un consenso de diagnóstico y tratamiento de sepsis con los siguientes ...
Marcos I. Restrepo, Carmelo Dueñas, Marco González, Guillermo Ortiz, Carlos Álvarez, Marcela Granados, Carlos Acosta, Arturo Arias, Luis H. Atehortúa, Rubén Camargo, Martín Carvajal, Gisela de la Rosa, Julio Durán, Juan L. Echeverri, Bladimir Gil, Carlos Hurtado, Ernesto Martínez, Carlos Rebolledo, Carlos Saavedra, Julio Sandoval, Julio Velandia, José A. Vélez, Juan D. Vélez, Representantes de los comités de la Asociación Colombiana de Medicina Intensiva y Cuidado Intensivo (AMCI) y la Asociación Colombiana de Infectología (ACIN)   +23 more
doaj  

Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution

Journal of Experimental Orthopaedics, 2019
Background ALM solution, a combination of adenosine, lidocaine and Mg2+, is an emerging small volume therapy that has been shown to prevent and correct coagulopathy and surgery-related inflammation in preclinical models, though its application in ...
Andrew McCutchan, Geoffrey P. Dobson, Natalie Stewart, Hayley L. Letson, Andrea L. Grant, Ivana-Aleksandra Jovanovic, Kaushik Hazratwala, Matthew Wilkinson, Peter McEwen, Jodie Morris   +9 more
doaj   +1 more source

Effects of glutamine and n-3 polyunsaturated fatty acid mixed lipid emulsion supplementation of parenteral nutrition on sepsis score and bacterial clearance in early experimental sepsis [PDF]

, 2023
Qing Ma, Paul E. Wischmeyer
openalex   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response

Journal of Lipid Research, 2013
Plasma secretion of acid sphingomyelinase is a hallmark of cellular stress response resulting in the formation of membrane embedded ceramide-enriched lipid rafts and the reorganization of receptor complexes.
Nayla Jbeily, Iris Suckert, Falk A. Gonnert, Benedikt Acht, Clemens L. Bockmeyer, Sascha D. Grossmann, Markus F. Blaess, Anja Lueth, Hans-Peter Deigner, Michael Bauer, Ralf A. Claus   +10 more
doaj   +1 more source

Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. [PDF]

, 2016
ObjectivesThiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal ...
Fang, Liwei, Said, Hamid M, Sassoon, Catherine S, Subramanian, Veedamali S, Zhu, Ercheng   +4 more
core   +2 more sources