Results 61 to 70 of about 604,208 (156)

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

Epigenetics of Sepsis

Critical Care Medicine, 2020
Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term “epigenetics” refers to regulatory mechanisms that control gene expression but are not related to ...
Pedro Castelo-Branco, Alexandra Binnie, Claudia C. dos Santos, Claudia C. dos Santos, Pingzhao Hu, Gabriela Carrasqueiro, Jennifer L Y Tsang   +6 more
openaire   +4 more sources

Zinc and Sepsis [PDF]

Nutrients, 2018
Sepsis, defined as a “life-threatening organ dysfunction caused by a dysregulated host-response to infection” is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response.
Wiebke Alker, Hajo Haase
openaire   +3 more sources

Model-Based Reinforcement Learning for Sepsis Treatment [PDF]

arXiv, 2018
Sepsis is a dangerous condition that is a leading cause of patient mortality. Treating sepsis is highly challenging, because individual patients respond very differently to medical interventions and there is no universally agreed-upon treatment for sepsis. In this work, we explore the use of continuous state-space model-based reinforcement learning (RL)
arxiv  

Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis [PDF]

, 2017
Background: Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the clinical variables would improve ...
Hanah Kim, Hee-Won Moon, Mina Hur, null null, Salvatore Di Somma, Yeo-Min Yun   +5 more
core   +2 more sources

The Evolving Definition of Sepsis [PDF]

arXiv, 2016
Sepsis affects millions of people worldwide each year. It occurs when a normal human immune response to a bacterial, viral or fungal infection becomes dysfunctional and triggers widespread inflammation that results in severe tissue damage that leads to organ failure, shock, and death. Sepsis, requires immediate treatment and has a high readmission rate
arxiv  

Improving Early Sepsis Prediction with Multi Modal Learning [PDF]

arXiv, 2021
Sepsis is a life-threatening disease with high morbidity, mortality and healthcare costs. The early prediction and administration of antibiotics and intravenous fluids is considered crucial for the treatment of sepsis and can save potentially millions of lives and billions in health care costs.
arxiv  

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. [PDF]

, 2017
OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012." DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened.
Alhazzani, W, Angus, DC, Annane, D, Antonelli, M, Beale, RJ, Bellinghan, GJ, Bernard, GR, Chiche, J-D, Coopersmith, C, De Backer, DP, Dellinger, RP, Evans, LE, Ferrer, R, French, CJ, Fujishima, S, Gerlach, H, Hidalgo, JL, Hollenberg, SM, Jones, AE, Karnad, DR, Kleinpell, RM, Koh, Y, Kumar, A, Levy, MM, Lisboa, TC, Machado, FR, Marini, JJ, Marshall, JC, Mazuski, JE, McIntyre, LA, McLean, AS, Mehta, S, Moreno, RP, Myburgh, J, Navalesi, P, Nishida, O, Nunnally, ME, Osborn, TM, Perner, A, Plunkett, CM, Ranieri, M, Rhodes, A, Rochwerg, B, Rubenfeld, GD, Schorr, CA, Seckel, MA, Sevransky, JE, Seymour, CW, Shieh, L, Shukri, KA, Simpson, SQ, Singer, M, Sprung, CL, Thompson, BT, Townsend, SR, Van der Poll, T, Vincent, J-L, Wiersinga, WJ, Zimmerman, JL   +58 more
core   +4 more sources

Sepsis

, 2014
The management of the child with sepsis represents the sine qua non of pediatric critical care medicine. Overwhelming sepsis and septic shock often manifest with concurrent derangements of cardiovascular function, intravascular volume status, respiratory function, immune regulation, renal function, coagulation, hepatic function, and metabolic function –
Wynn, James L., Hazelzet, Jan A., Shanley, Thomas P., Wong, Hector R., Wheeler, Derek S.   +4 more
openaire   +1 more source

Soluble suppression of tumorigenicity 2 and echocardiography in sepsis [PDF]

, 2016
Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. However, its role in sepsis-induced cardiac dysfunction is still unknown.
Hanah Kim, Hyun Suk Yang, Laura Magrini, Mina Hur, null null, Rossella Marino, Salvatore Di Somma   +6 more
core   +1 more source