Results 21 to 30 of about 148,562 (307)

Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH). [PDF]

, 2014
INTRODUCTION: Vasopressin is an alternative vasopressor in the management of septic shock. It spares catecholamine use but whether it improves outcome remains uncertain.
Brett, Stephen J., Gordon, AC, Perkins, GD, Brett, Stephen J, Brett, SJ, Mason, Alexina J., Mason, Alexina J, Ashby, D, Perkins, Gavin D., Gordon, Anthony C., Perkins, Gavin D, Ashby, Deborah, Mason, AJ, Gordon, Anthony C   +13 more
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The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study [PDF]

, 2011
Contains fulltext : 98426.pdf (Publisher’s version ) (Open Access)ABSTRACT: OBJECTIVE: This study was designed to investigate the effect of hypertonic fluid administration on inflammatory mediator gene expression in patients with septic
James Sleigh, Haren, F.M.P. van, Sleigh, James W., Cursons, Raymond T., Pine, M. La, Mary La Pine, Cursons, R., Hoeven, J.G. van der, van Haren, Frank MP, Sleigh, J., van der Hoeven, Johannes, Ray Cursons, Johannes G van der Hoeven, Pickkers, Peter, Pickkers, P., Pine, Mary L., Frank MP van Haren, Peter Pickkers   +17 more
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Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis

Медицинская иммунология, 2020
Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj   +1 more source

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. [PDF]

, 2010
In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on ...
Aladzsity, István, Prohászka Zoltán, Madách Krisztina, Füst György, Pénzes, István, Gál János, Pénzes István, Madách, Krisztina, Prohászka, Zoltán, Szilágyi Ágnes, Aladzsity István, Szilágyi, Agnes, Fust, George, Gál, János   +13 more
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Septic Shock

Veterinary Clinics of North America: Small Animal Practice, 1989
Septic shock is a life-threatening condition that results from the combined effects of bacteria and the host's chemical mediators of inflammation. Of particular detriment is the hyperdynamic and hypodynamic vasomotor instability that severely compromises the patient prior to the onset of overt bacteremia.
Resident, From the Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida ( host institution ), Goodwin, John-Karl ( author ), Schaer, Michael ( author )   +2 more
openaire   +3 more sources

The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. [PDF]

, 2014
BACKGROUND: Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated ...
McAuley, Daniel F, Orme, RML, Singer, M, L'E Orme, Robert M, Alexina J Mason, McAuley DF, Mason, Alexina J., Orme, Robert M L'E, Ashby D, Orme, Robert M., Mason, Alexina J, Liu, KD, Perkins, Gavin D., McAuley, Daniel F.; id_orcid, Gordon, Anthony C., Robert M Orme, Daniel F McAuley, Mason, AJ, Gordon, Anthony C, Gordon AC, Liu, Kathleen D., Orme RM, Gordon, AC, Mervyn Singer, Perkins, GD, Kathleen D Liu, Mason AJ, McAuley, Daniel F., Liu KD, Andrea Morelli, Ashby, D, Liu, Kathleen, Liu, Kathleen D, Gavin D Perkins, Morelli, A, Singer, Mervyn, Singer M, Perkins, Gavin D, Ashby, Deborah, Anthony C Gordon, Deborah Ashby, Orme, Robert MLE, Morelli, Andrea, Perkins GD, McAuley, DF   +44 more
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Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock

Biomedicines, 2022
(1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García, Rebeca Osca-Verdegal, Beatriz Jávega, Guadalupe Herrera, José-Enrique O’Connor, Eva García-López, Germán Casabó-Vallés, María Rodriguez-Gimillo, José Ferreres, Nieves Carbonell, Federico V. Pallardó, José Luis García-Giménez   +11 more
doaj   +1 more source

Serum Soluble Endoglin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome

, 2023
Background: Endothelial activation is a key driver of multiple organ dysfunction syndrome (MODS). Soluble endoglin (sENG) is expressed by mature and progenitor endothelial cells and thought to have angiogenic properties.
Weiss, Scott L., Haileselassie, Bereketeab, Zingarelli, Basilia, Lutfi, Riad, Bigham, Michael T., Thomas, Neal J., Schwarz, Adam J., Jain, Parag N., Fitzgerald, Julie C., Cvijanovich, Natalie Z., Quasney, Michael, Baines, Torrey D., Atreya, Mihir R., Nowak, Jeffrey, Genomics of Pediatric Septic Shock Investigators   +14 more
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Sepsis and Septic Shock: Outcomes in Elderly and Very Elderly Intensive Care Patients

, 2022
Objective:The relationship between age and the development and outcome of sepsis and septic shock is unclear, especially in adults. There are few studies about the incidence, prognosis and mortality rates of sepsis in elderly and very elderly patients ...
Kamil İnci, Inci, KAMİL, Gülbin Aygencel, Melda Türkoğlu, Aygencel, Guelbin, Burcu Candemir, Candemir, Burcu, Turkoglu, Melda   +7 more
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