Results 21 to 30 of about 126,820 (261)

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock

Biomedicines, 2022
(1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García, Rebeca Osca-Verdegal, Beatriz Jávega, Guadalupe Herrera, José-Enrique O’Connor, Eva García-López, Germán Casabó-Vallés, María Rodriguez-Gimillo, José Ferreres, Nieves Carbonell, Federico V. Pallardó, José Luis García-Giménez   +11 more
doaj   +1 more source

Septic shock

Journal of British Surgery, 1975
Abstract The problems associated with septic shock are highlighted, including those which arose during a 3-year prospective study. Mortality in the first year of the study was 71 per cent, falling to 38 per cent in the third year. The reasons, for this fall are detailed. The pattern of survival times changed over the 3 years, giving rise
openaire   +4 more sources

CD63 and C3AR1: The Potential Molecular Targets in the Progression of Septic Shock

International Journal of General Medicine, 2022
Ning Yu, Xuefang Liu, Dandan Shi, Long Bai, Tianfu Niu, Ya Liu Department of Anaesthesiology and Intensive Care, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050004, People’s Republic of ChinaCorrespondence: Ya Liu,
Yu N, Liu X, Shi D, Bai L, Niu T, Liu Y
doaj  

Septic shock

Акушерство, гинекология и репродукция, 2020
The problem of sepsis and septic shock has recently become more and more actual. In obstetrics and gynaecology, the number of cases of sepsis has more than doubled over the past 10 years.
V. O. Bitsadze, T. A. Sukontseva, S. V. Akinshina, Ya. Yu. Sulina, J. Kh. Khizroeva, M. V. Tretyakova, Kh. G. Sultangadzhieva, J. Yu. Ungiadze, N. V. Samburova, K. N. Grigoreva, V. I. Tsibizova, A. S. Shkoda, D. V. Blinov, A. D. Makatsariya   +13 more
doaj   +1 more source

Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury

Hereditas, 2021
Background Sepsis and septic shock are life-threatening diseases with high mortality rate in intensive care unit (ICU). Acute kidney injury (AKI) is a common complication of sepsis, and its occurrence is a poor prognostic sign to septic patients.
Yun Tang, Xiaobo Yang, Huaqing Shu, Yuan Yu, Shangwen Pan, Jiqian Xu, You Shang   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Diagnostic values of TPT1 in patients with sepsis, septic shock and in non-infected controls: A single-center prospective observational cohort study in ICU patients

Science Progress
Objective To evaluate the diagnostic value of tumor protein translationally-controlled 1 (TPT1) in patients with sepsis and septic shock in the intensive care unit (ICU).
Gelan Miao, Dexiu Chen, Xuelian Yang, Yulian Yang, Qidong Jiang, Li Liu, Xianying Lei   +6 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database

European Journal of Medical Research
Background Septic shock, a severe consequence of sepsis, has a high mortality rate. Hypothermia can aggravate the state of septic shock patients, which influences therapeutic response and overall prognosis.
Fen Tan, Jinxiu Li, Yang Xiao, Chenfang Wu   +3 more
doaj   +1 more source