Results 31 to 40 of about 637,709 (306)
Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood [PDF]
, 2007 Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann, Matthias +11 more
core +1 more source
An overview of the mechanisms and potential roles of extracellular vesicles in septic shock
Frontiers in ImmunologySeptic shock, a subset of sepsis, is a fatal condition associated with high morbidity and mortality. However, the pathophysiology of septic shock is not fully understood. Moreover, the diagnostic markers employed for identifying septic shock lack optimal
Meiling Cao +3 more
doaj +1 more source
Mortality prediction using the Shock Index and Modified Shock Index in the Emergency Department [PDF]
Revista Brasileira de EnfermagemObjectives: to compare the Shock Index and the Modified Shock Index in predicting in-hospital mortality among patients diagnosed with shock and admitted to the Emergency Department.
Karoline Maciel Lopes +7 more
doaj +4 more sources
Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock
Biomedicines, 2022 (1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García +11 more
doaj +1 more source
Journal of British Surgery, 1975 Abstract The problems associated with septic shock are highlighted, including those which arose during a 3-year prospective study. Mortality in the first year of the study was 71 per cent, falling to 38 per cent in the third year. The reasons, for this fall are detailed. The pattern of survival times changed over the 3 years, giving rise
openaire +4 more sources
, 2022 Objectives: Definition and epidemiology of septic shock Early goal directed therapy Targets during resuscitation Timing of treatment How much fluids is enough?
Elkhapery, Ahmed
core +2 more sources
CD63 and C3AR1: The Potential Molecular Targets in the Progression of Septic Shock
International Journal of General Medicine, 2022 Ning Yu, Xuefang Liu, Dandan Shi, Long Bai, Tianfu Niu, Ya Liu Department of Anaesthesiology and Intensive Care, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050004, People’s Republic of ChinaCorrespondence: Ya Liu,
Yu N, Liu X, Shi D, Bai L, Niu T, Liu Y
doaj
BMC Infectious DiseasesSepsis and septic shock stimulate a massive inflammatory response during which neutrophil extracellular traps (NETs) release citrullinated histone H3 (CitH3) into the circulation, leading to tissue damage, coagulopathy, and organ failure.
Nadia Mostafa Mohamed +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Nature Reviews Disease Primers, 2016 For more than two decades, sepsis was defined as a microbial infection that produces fever (or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now increasingly being considered a dysregulated systemic inflammatory and immune response to microbial invasion that produces organ injury for which mortality rates are declining to
Hotchkiss, Richard R.S. +5 more
openaire +5 more sources