Results 31 to 40 of about 609,887 (206)

Rate of Admission and Risk Factors of Sepsis and Septic Shock Patients in Emergency Intensive Care Unit [PDF]

Zagazig University Medical Journal
Background: Every year, millions of people are affected with sepsis and septic shock, which pose significant challenges to healthcare providers. Septic shock is the most severe form of sepsis.
Hatem Raafat Mostafa El-Malah, Adel Botros, Khaled Abdelhameed   +2 more
doaj   +1 more source

A model of porcine polymicrobial septic shock

Intensive Care Medicine Experimental, 2023
Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades.
Finnja Marie Zurek-Leffers, Florian Lehmann, Laura Brabenec, Sebastian Kintrup, Katharina E. M. Hellenthal, Kira Mersjann, Felicia Kneifel, Michael Hessler, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Christian Ertmer, Patrick Kellner, Nana-Maria Wagner   +12 more
doaj   +1 more source

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. [PDF]

, 2010
In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on ...
Aladzsity, István, Prohászka Zoltán, Madách Krisztina, Füst György, Pénzes, István, Gál János, Pénzes István, Madách, Krisztina, Prohászka, Zoltán, Szilágyi Ágnes, Aladzsity István, Szilágyi, Agnes, Fust, George, Gál, János   +13 more
core   +1 more source

The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source

Major sepsis study confirms back to basics approach [PDF]

, 2014
In 2001 Rivers et al. published a landmark study in the New England Journal of Medicine showing that in a single centre, involving patients presenting to an emergency department with severe sepsis and septic shock, an early goal-directed therapy (EGDT ...
Nathwani, D.
core   +1 more source

Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis

Медицинская иммунология, 2020
Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj   +1 more source

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. [PDF]

, 2014
BACKGROUND: Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated ...
McAuley, Daniel F, Orme, RML, Singer, M, L'E Orme, Robert M, Alexina J Mason, McAuley DF, Mason, Alexina J., Orme, Robert M L'E, Ashby D, Orme, Robert M., Mason, Alexina J, Liu, KD, Perkins, Gavin D., McAuley, Daniel F.; id_orcid, Gordon, Anthony C., Robert M Orme, Daniel F McAuley, Mason, AJ, Gordon, Anthony C, Gordon AC, Liu, Kathleen D., Orme RM, Gordon, AC, Mervyn Singer, Perkins, GD, Kathleen D Liu, Mason AJ, McAuley, Daniel F., Liu KD, Andrea Morelli, Ashby, D, Liu, Kathleen, Liu, Kathleen D, Gavin D Perkins, Morelli, A, Singer, Mervyn, Singer M, Perkins, Gavin D, Ashby, Deborah, Anthony C Gordon, Deborah Ashby, Orme, Robert MLE, Morelli, Andrea, Perkins GD, McAuley, DF   +44 more
core   +1 more source

Septic Shock

Veterinary Clinics of North America: Small Animal Practice, 1989
Septic shock is a life-threatening condition that results from the combined effects of bacteria and the host's chemical mediators of inflammation. Of particular detriment is the hyperdynamic and hypodynamic vasomotor instability that severely compromises the patient prior to the onset of overt bacteremia.
Resident, From the Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida ( host institution ), Goodwin, John-Karl ( author ), Schaer, Michael ( author )   +2 more
openaire   +3 more sources

Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood [PDF]

, 2007
Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann, Matthias, Christoph Sucker, Zacharowski, Kai, Hartmann, Matthias, Kai Zacharowski, Matthias Thielmann, Sucker, Christoph, Sucker Christoph, Thielmann Matthias, Matthias Hartmann, Zacharowski Kai, Hartmann Matthias   +11 more
core   +1 more source

Managing septic shock [PDF]

F1000 Medicine Reports, 2010
Although several successful clinical trials in the last 2-3 years have been greeted with enthusiasm by intensivists, severe sepsis and septic shock still have increasing incidence and more or less unchanged mortality. Within the last few years, the progress in sepsis research covering definitions, epidemiology, pathophysiology, diagnosis, and standard ...
Gerlach, Herwig, Toussaint, Susanne
openaire   +2 more sources