Results 41 to 50 of about 227,863 (293)

Empiric Antimicrobial Therapy in Patients with Healthcare-Associated, Hospital-Acquired, or Ventilator-Associated Pneumonia in Septic Shock: Does Antimicrobial Reuse Influence Outcomes? [PDF]

, 2017
Appropriate empiric antimicrobial selection is crucial to the survival of septic shock patients. It is suspected that the use of inadequate empiric therapy occurs commonly in practice.
Stagge, Nicole
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Septic shock

Journal of British Surgery, 1975
Abstract The problems associated with septic shock are highlighted, including those which arose during a 3-year prospective study. Mortality in the first year of the study was 71 per cent, falling to 38 per cent in the third year. The reasons, for this fall are detailed. The pattern of survival times changed over the 3 years, giving rise
openaire   +4 more sources

Identification of transcriptomics biomarkers for the early prediction of the prognosis of septic shock from pneumopathies

BMC Infectious Diseases, 2021
Background Identifying the biological subclasses of septic shock might provide specific targeted therapies for the treatment and prognosis of septic shock. It might be possible to find biological markers for the early prediction of septic shock prognosis.
Songchang Shi, Xiaobin Pan, Hangwei Feng, Shujuan Zhang, Songjing Shi, Wei Lin   +5 more
doaj   +1 more source

Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot study [PDF]

, 2009
INTRODUCTION: The application in clinical practice of evidence-based guidelines for the management of patients with severe sepsis/septic shock is still poor in the emergency department, while little data are available for patients admitted to the ...
Claudia Venturelli, Lara Donno, Laura Rinaldi, Marco Marietta, Massimo Girardis, Mauro Codeluppi, null null, Patrizia Marchegiano   +7 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Diagnostic values of TPT1 in patients with sepsis, septic shock and in non-infected controls: A single-center prospective observational cohort study in ICU patients

Science Progress
Objective To evaluate the diagnostic value of tumor protein translationally-controlled 1 (TPT1) in patients with sepsis and septic shock in the intensive care unit (ICU).
Gelan Miao, Dexiu Chen, Xuelian Yang, Yulian Yang, Qidong Jiang, Li Liu, Xianying Lei   +6 more
doaj   +1 more source

The Physiological Basis for Vitamin C as a Potential Treatment for Sepsis [PDF]

, 2019
Accounting for one third of all hospital patient deaths in America, sepsis remains one of the most deadly and complicated conditions that healthcare providers treat.
Johnston, Jennifer
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database

European Journal of Medical Research
Background Septic shock, a severe consequence of sepsis, has a high mortality rate. Hypothermia can aggravate the state of septic shock patients, which influences therapeutic response and overall prognosis.
Fen Tan, Jinxiu Li, Yang Xiao, Chenfang Wu   +3 more
doaj   +1 more source