Results 81 to 90 of about 1,124,600 (388)

Diagnostic and Prognostic Significance of the Prothrombin Time/International Normalized Ratio in Sepsis and Septic Shock

Clinical and Applied Thrombosis/Hemostasis, 2022
Objective The study investigates the diagnostic and prognostic significance of the prothrombin time/international normalized ratio (PT/INR) in patients with sepsis and septic shock.
Tobias Schupp MD, Kathrin Weidner MD, Jonas Rusnak MD, Schanas Jawhar MS, Jan Forner MS, Floriana Dulatahu MS, Lea Marie Brück MS, Ursula Hoffmann MD, Thomas Bertsch MD, Julian Müller MD, Christel Weiß PhD, Ibrahim Akin MD, Michael Behnes MD   +12 more
doaj   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Microbiological and Clinical Characteristics of Pediatric Sepsis Patients with and without Septic Shock: A Retrospective Study at a Tertiary Pediatric Hospital in China

Children
Background: Pediatric sepsis, a life-threatening condition, often progresses to septic shock. However, microbiological and clinical profiles between pediatric sepsis patients with and without septic shock remain underexplored. Methods: This retrospective
Kai-Cheng Peng, Qin-Yuan Li, Lin Chen, Yan Zhao, Hui Liu, Zhen-Xuan Kong, Zheng-Xiu Luo   +6 more
doaj   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis [PDF]

, 2019
BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biologically active adrenomedullin (bio-ADM) is an emerging biomarker for sepsis.
Bergmann, A., Di Somma, S., Hur, M., Kim, H., Struck, J.   +4 more
core   +1 more source

Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study

Intensive Care Medicine, 2020
To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock.
S. Hwang, S. Ryoo, Jong Eun Park, Y. Jo, Dong-Hyun Jang, G. Suh, Taegyun Kim, Youn-Jung Kim, Seonwoo Kim, Hyun Cho, I. Jo, S. Chung, Sung-Hyuk Choi, T. Shin, W. Kim   +14 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Baseline Values of Left Ventricular Systolic Function in Preterm Infants With Septic Shock: A Prospective Observational Study

Frontiers in Pediatrics, 2022
Background and AimGuidelines recommended that cardiac index (CI) of term infants with septic shock should reach the target level of 3.3–6.0L/(min⋅m2). However, there are still no standard values for preterm infants with septic shock.
Junjuan Zhong, Chun Shuai, Yue Wang, Jing Mo, Dongju Ma, Jing Zhang, Yingyi Lin, Jie Yang, Xiuzhen Ye   +8 more
doaj   +1 more source

Levosimendan in Sepsis. [PDF]

, 2017
Commentum to "Levosimendan for the Prevention of Acute Organ Dysfunction in ...
Morelli, Andrea, Tritapepe, Luigi
core   +1 more source

Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock

Critical Care, 2020
Background Platelets have been demonstrated to be potent activators of neutrophil extracellular trap (NET) formation during sepsis. However, the mediators and molecular pathways involved in human platelet-mediated NET generation remain poorly defined ...
Yang Jiao, Weiwei Li, Wei Wang, Xingyu Tong, Ran Xia, Jie Fan, Jianer Du, Chengmi Zhang, Xueyin Shi   +8 more
semanticscholar   +1 more source