Results 81 to 90 of about 1,087,361 (389)

The Physiological Basis for Vitamin C as a Potential Treatment for Sepsis [PDF]

, 2019
Accounting for one third of all hospital patient deaths in America, sepsis remains one of the most deadly and complicated conditions that healthcare providers treat.
Johnston, Jennifer
core   +1 more source

The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: A meta-analysis of randomized controlled trials [PDF]

, 2014
__Introduction:__ The Surviving Sepsis Campaign guidelines recommend goal-directed therapy (GDT) for the early resuscitation of patients with sepsis. However, the findings of the ProCESS (Protocolized Care for Early Septic Shock) trial showed no benefit ...
Bakker, J. (Jan), Gu, W.-J. (Wan-Jie), Liu, J.-C. (Jing-Chen), Tang, L. (Lu), Wang, F. (Fei)   +4 more
core   +3 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

The Systemic Alterations of Lipids, Alanine-Glucose Cycle and Inter-Organ Amino Acid Metabolism in Swine Model Confirms the Role of Liver in Early Phase of Septic Shock

Frontiers in Physiology, 2019
Septic shock is a medical emergency and is one of the main causes of mortality in critically ill patients. Given the pathophysiological complexity of sepsis spectrum and progression in clinical settings, animal models become essential tools to improve ...
Manuela Ferrario, Laura Brunelli, Fuhong Su, Antoine Herpain, Antoine Herpain, Roberta Pastorelli   +5 more
doaj   +1 more source

Baseline Values of Left Ventricular Systolic Function in Preterm Infants With Septic Shock: A Prospective Observational Study

Frontiers in Pediatrics, 2022
Background and AimGuidelines recommended that cardiac index (CI) of term infants with septic shock should reach the target level of 3.3–6.0L/(min⋅m2). However, there are still no standard values for preterm infants with septic shock.
Junjuan Zhong, Chun Shuai, Yue Wang, Jing Mo, Dongju Ma, Jing Zhang, Yingyi Lin, Jie Yang, Xiuzhen Ye   +8 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

The prevalence of severe sepsis or septic shock in an Irish emergency department [PDF]

, 2018
Severe sepsis and septic shock are among the leading causes of death globally. Despite the central role the emergency department (ED) plays in the early identification of patients presenting to hospital with sepsis, the prevalence of severe sepsis and ...
Fitzpatrick, Fidelma, McDowell, Dermot, McNevin, Ciara, O'Sullivan, Ronan, Wakai, Abel   +4 more
core  

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Septic Shock

Acta Clinica Belgica, 1975
Abstract The problems associated with septic shock are highlighted, including those which arose during a 3-year prospective study. Mortality in the first year of the study was 71 per cent, falling to 38 per cent in the third year. The reasons, for this fall are detailed. The pattern of survival times changed over the 3 years, giving rise
openaire   +4 more sources

Trial of early, goal-directed resuscitation for septic shock.

New England Journal of Medicine, 2015
BACKGROUND Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock.
P. Mouncey, T. Osborn, G. S. Power, D. Harrison, M. Sadique, R. Grieve, Rahi Jahan, S. Harvey, D. Bell, J. Bion, T. Coats, M. Singer, J. D. Young, K. Rowan, A. Act   +14 more
semanticscholar   +1 more source